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dc.contributor.author Fusco, Diana en_US
dc.date.accessioned 2011-06-21T17:30:26Z
dc.date.available 2011-06-21T17:30:26Z
dc.date.issued 2010 en_US
dc.identifier.citation Fusco,Diana;Grassi,Luigi;Bassetti,Bruno;Caselle,Michele;Lagomarsino,Marco Cosentino. 2010. Ordered structure of the transcription network inherited from the yeast whole-genome duplication. Bmc Systems Biology 4( ): 77-77. en_US
dc.identifier.issn 1752-0509 en_US
dc.identifier.uri http://hdl.handle.net/10161/4387
dc.description.abstract Background: Gene duplication, a major evolutionary path to genomic innovation, can occur at the scale of an entire genome. One such "whole-genome duplication" (WGD) event among the Ascomycota fungi gave rise to genes with distinct biological properties compared to small-scale duplications. Results: We studied the evolution of transcriptional interactions of whole-genome duplicates, to understand how they are wired into the yeast regulatory system. Our work combines network analysis and modeling of the large-scale structure of the interactions stemming from the WGD. Conclusions: The results uncover the WGD as a major source for the evolution of a complex interconnected block of transcriptional pathways. The inheritance of interactions among WGD duplicates follows elementary "duplication subgraphs", relating ancestral interactions with newly formed ones. Duplication subgraphs are correlated with their neighbours and give rise to higher order circuits with two elementary properties: newly formed transcriptional pathways remain connected (paths are not broken), and are preferentially cross-connected with ancestral ones. The result is a coherent and connected "WGD-network", where duplication subgraphs are arranged in an astonishingly ordered configuration. en_US
dc.language.iso en_US en_US
dc.publisher BIOMED CENTRAL LTD en_US
dc.relation.isversionof doi:10.1186/1752-0509-4-77 en_US
dc.subject saccharomyces-cerevisiae en_US
dc.subject regulatory network en_US
dc.subject evolution en_US
dc.subject consequences en_US
dc.subject aneuploidy en_US
dc.subject mathematical & computational biology en_US
dc.title Ordered structure of the transcription network inherited from the yeast whole-genome duplication en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US
duke.date.pubdate 2010-6-3 en_US
duke.description.endpage 77 en_US
duke.description.issue en_US
duke.description.startpage 77 en_US
duke.description.volume 4 en_US
dc.relation.journal Bmc Systems Biology en_US

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