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dc.contributor.author Thiagarajan, TC
dc.contributor.author Lebedev, MA
dc.contributor.author Nicolelis, MA
dc.contributor.author Plenz, D
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:31:05Z
dc.date.issued 2010-01-12
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20084093
dc.identifier.citation PLoS Biol, 2010, 8 (1), pp. e1000278 - ?
dc.identifier.uri http://hdl.handle.net/10161/4441
dc.description.abstract Transient associations among neurons are thought to underlie memory and behavior. However, little is known about how such associations occur or how they can be identified. Here we recorded ongoing local field potential (LFP) activity at multiple sites within the cortex of awake monkeys and organotypic cultures of cortex. We show that when the composite activity of a local neuronal group exceeds a threshold, its activity pattern, as reflected in the LFP, occurs without distortion at other cortex sites via fast synaptic transmission. These large-amplitude LFPs, which we call coherence potentials, extend up to hundreds of milliseconds and mark periods of loss-less spread of temporal and amplitude information much like action potentials at the single-cell level. However, coherence potentials have an additional degree of freedom in the diversity of their waveforms, which provides a high-dimensional parameter for encoding information and allows identification of particular associations. Such nonlinear behavior is analogous to the spread of ideas and behaviors in social networks.
dc.format.extent e1000278 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS Biol
dc.relation.isversionof 10.1371/journal.pbio.1000278
dc.subject Animals
dc.subject Cerebral Cortex
dc.subject Macaca mulatta
dc.subject Models, Neurological
dc.subject Nerve Net
dc.subject Neurons
dc.subject Synaptic Transmission
dc.title Coherence potentials: loss-less, all-or-none network events in the cortex.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-1-0 en_US
duke.description.endpage e1000278 en_US
duke.description.issue 1 en_US
duke.description.startpage e1000278 en_US
duke.description.volume 8 en_US
dc.relation.journal Plos Biology en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20084093
pubs.issue 1
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Neurobiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Neurology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Neurology/Neurology, Behavioral Neurology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Orthopaedics
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Psychology and Neuroscience
pubs.publication-status Published online
pubs.volume 8
dc.identifier.eissn 1545-7885

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