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dc.contributor.author Zeller, Raymond M. en_US
dc.date.accessioned 2011-06-21T17:31:16Z
dc.date.available 2011-06-21T17:31:16Z
dc.date.issued 2010 en_US
dc.identifier.citation Hazkani-Covo,Einat;Zeller,Raymond M.;Martin,William. 2010. Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes. Plos Genetics 6(2): e1000834-e1000834. en_US
dc.identifier.issn 1553-7390 en_US
dc.identifier.uri http://hdl.handle.net/10161/4462
dc.description.abstract The natural transfer of DNA from mitochondria to the nucleus generates nuclear copies of mitochondrial DNA (numts) and is an ongoing evolutionary process, as genome sequences attest. In humans, five different numts cause genetic disease and a dozen human loci are polymorphic for the presence of numts, underscoring the rapid rate at which mitochondrial sequences reach the nucleus over evolutionary time. In the laboratory and in nature, numts enter the nuclear DNA via non-homolgous end joining (NHEJ) at double-strand breaks (DSBs). The frequency of numt insertions among 85 sequenced eukaryotic genomes reveal that numt content is strongly correlated with genome size, suggesting that the numt insertion rate might be limited by DSB frequency. Polymorphic numts in humans link maternally inherited mitochondrial genotypes to nuclear DNA haplotypes during the past, offering new opportunities to associate nuclear markers with mitochondrial markers back in time. en_US
dc.language.iso en_US en_US
dc.publisher PUBLIC LIBRARY SCIENCE en_US
dc.relation.isversionof doi:10.1371/journal.pgen.1000834 en_US
dc.subject yeast saccharomyces-cerevisiae en_US
dc.subject human genetic-disease en_US
dc.subject double-strand en_US
dc.subject breaks en_US
dc.subject promiscuous dna en_US
dc.subject organelle dna en_US
dc.subject domestic cat en_US
dc.subject evolution en_US
dc.subject pseudogenes en_US
dc.subject insertions en_US
dc.subject chromosomes en_US
dc.subject genetics & heredity en_US
dc.title Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US
duke.date.pubdate 2010-2-0 en_US
duke.description.endpage e1000834 en_US
duke.description.issue 2 en_US
duke.description.startpage e1000834 en_US
duke.description.volume 6 en_US
dc.relation.journal Plos Genetics en_US

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