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dc.contributor.author Tsai, FJ
dc.contributor.author Yang, CF
dc.contributor.author Chen, CC
dc.contributor.author Chuang, LM
dc.contributor.author Lu, CH
dc.contributor.author Chang, CT
dc.contributor.author Wang, TY
dc.contributor.author Chen, RH
dc.contributor.author Shiu, CF
dc.contributor.author Liu, YM
dc.contributor.author Chang, CC
dc.contributor.author Chen, P
dc.contributor.author Chen, CH
dc.contributor.author Fann, CS
dc.contributor.author Chen, YT
dc.contributor.author Wu, JY
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:31:16Z
dc.date.issued 2010-02-19
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20174558
dc.identifier.citation PLoS Genet, 2010, 6 (2), pp. e1000847 - ?
dc.identifier.uri http://hdl.handle.net/10161/4464
dc.description.abstract To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes susceptibility genes that increase the risk of type 2 diabetes (T2D) in a Han Chinese population. A two-stage genome-wide association (GWA) study was conducted, in which 995 patients and 894 controls were genotyped using the Illumina HumanHap550-Duo BeadChip for the first genome scan stage. This was further replicated in 1,803 patients and 1,473 controls in stage 2. We found two loci not previously associated with diabetes susceptibility in and around the genes protein tyrosine phosphatase receptor type D (PTPRD) (P = 8.54x10(-10); odds ratio [OR] = 1.57; 95% confidence interval [CI] = 1.36-1.82), and serine racemase (SRR) (P = 3.06x10(-9); OR = 1.28; 95% CI = 1.18-1.39). We also confirmed that variants in KCNQ1 were associated with T2D risk, with the strongest signal at rs2237895 (P = 9.65x10(-10); OR = 1.29, 95% CI = 1.19-1.40). By identifying two novel genetic susceptibility loci in a Han Chinese population and confirming the involvement of KCNQ1, which was previously reported to be associated with T2D in Japanese and European descent populations, our results may lead to a better understanding of differences in the molecular pathogenesis of T2D among various populations.
dc.format.extent e1000847 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS Genet
dc.relation.isversionof 10.1371/journal.pgen.1000847
dc.subject Adult
dc.subject Asian Continental Ancestry Group
dc.subject Case-Control Studies
dc.subject China
dc.subject Diabetes Mellitus, Type 2
dc.subject Ethnic Groups
dc.subject Female
dc.subject Genetic Loci
dc.subject Genetic Predisposition to Disease
dc.subject Genome-Wide Association Study
dc.subject Humans
dc.subject KCNQ1 Potassium Channel
dc.subject Male
dc.subject Polymorphism, Single Nucleotide
dc.subject Reproducibility of Results
dc.title A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-2-0 en_US
duke.description.endpage e1000847 en_US
duke.description.issue 2 en_US
duke.description.startpage e1000847 en_US
duke.description.volume 6 en_US
dc.relation.journal Plos Genetics en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20174558
pubs.issue 2
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pediatrics
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pediatrics/Pediatrics, Medical Genetics
pubs.publication-status Published online
pubs.volume 6
dc.identifier.eissn 1553-7404

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