Show simple item record Suchindran, S Rivedal, D Guyton, JR Milledge, T Gao, X Benjamin, A Rowell, J Ginsburg, GS McCarthy, JJ
dc.coverage.spatial United States 2011-06-21T17:31:17Z 2010-04-29
dc.identifier.citation PLoS Genet, 2010, 6 (4), pp. e1000928 - ?
dc.description.abstract Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor and therapeutic target for cardiovascular disease. The activity and mass of this enzyme are heritable traits, but major genetic determinants have not been explored in a systematic, genome-wide fashion. We carried out a genome-wide association study of Lp-PLA(2) activity and mass in 6,668 Caucasian subjects from the population-based Framingham Heart Study. Clinical data and genotypes from the Affymetrix 550K SNP array were obtained from the open-access Framingham SHARe project. Each polymorphism that passed quality control was tested for associations with Lp-PLA(2) activity and mass using linear mixed models implemented in the R statistical package, accounting for familial correlations, and controlling for age, sex, smoking, lipid-lowering-medication use, and cohort. For Lp-PLA(2) activity, polymorphisms at four independent loci reached genome-wide significance, including the APOE/APOC1 region on chromosome 19 (p = 6 x 10(-24)); CELSR2/PSRC1 on chromosome 1 (p = 3 x 10(-15)); SCARB1 on chromosome 12 (p = 1x10(-8)) and ZNF259/BUD13 in the APOA5/APOA1 gene region on chromosome 11 (p = 4 x 10(-8)). All of these remained significant after accounting for associations with LDL cholesterol, HDL cholesterol, or triglycerides. For Lp-PLA(2) mass, 12 SNPs achieved genome-wide significance, all clustering in a region on chromosome 6p12.3 near the PLA2G7 gene. Our analyses demonstrate that genetic polymorphisms may contribute to inter-individual variation in Lp-PLA(2) activity and mass.
dc.format.extent e1000928 - ?
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof PLoS Genet
dc.relation.isversionof 10.1371/journal.pgen.1000928
dc.subject 1-Alkyl-2-acetylglycerophosphocholine Esterase
dc.subject Cardiovascular Diseases
dc.subject Genetic Predisposition to Disease
dc.subject Genome, Human
dc.subject Genome-Wide Association Study
dc.subject Genotype
dc.subject Humans
dc.subject Polymorphism, Single Nucleotide
dc.subject Risk Factors
dc.title Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-4-0 en_US
duke.description.endpage e1000928 en_US
duke.description.issue 4 en_US
duke.description.startpage e1000928 en_US
duke.description.volume 6 en_US
dc.relation.journal Plos Genetics en_US
pubs.issue 4
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Community and Family Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Cardiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Endocrinology, Metabolism, and Nutrition
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/School of Nursing
pubs.organisational-group /Duke/School of Nursing/School of Nursing
pubs.publication-status Published online
pubs.volume 6
dc.identifier.eissn 1553-7404

Files in this item

This item appears in the following Collection(s)

Show simple item record