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dc.contributor.author Zhao, Z
dc.contributor.author Taylor, WD
dc.contributor.author Styner, M
dc.contributor.author Steffens, DC
dc.contributor.author Krishnan, KR
dc.contributor.author MacFall, JR
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:31:22Z
dc.date.issued 2008-03-19
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/18350172
dc.identifier.citation PLoS One, 2008, 3 (3), pp. e1837 - ?
dc.identifier.uri http://hdl.handle.net/10161/4485
dc.description.abstract Major depression in the elderly is associated with brain structural changes and vascular lesions. Changes in the subcortical regions of the limbic system have also been noted. Studies examining hippocampus volumetric differences in depression have shown variable results, possibly due to any volume differences being secondary to local shape changes rather than differences in the overall volume. Shape analysis offers the potential to detect such changes. The present study applied spherical harmonic (SPHARM) shape analysis to the left and right hippocampi of 61 elderly subjects with major depression and 43 non-depressed elderly subjects. Statistical models controlling for age, sex, and total cerebral volume showed a significant reduction in depressed compared with control subjects in the left hippocampus (F(1,103) = 5.26; p = 0.0240) but not right hippocampus volume (F(1,103) = 0.41; p = 0.5213). Shape analysis showed significant differences in the mid-body of the left (but not the right) hippocampus between depressed and controls. When the depressed group was dichotomized into those whose depression was remitted at time of imaging and those who were unremitted, the shape comparison showed remitted subjects to be indistinguishable from controls (both sides) while the unremitted subjects differed in the midbody and the lateral side near the head. Hippocampal volume showed no difference between controls and remitted subjects but nonremitted subjects had significantly smaller left hippocampal volumes with no significant group differences in the right hippocampus. These findings may provide support to other reports of neurogenic effects of antidepressants and their relation to successful treatment for depressive symptoms.
dc.format.extent e1837 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0001837
dc.subject Age of Onset
dc.subject Aged
dc.subject Depression
dc.subject Hippocampus
dc.subject Humans
dc.subject Magnetic Resonance Imaging
dc.title Hippocampus shape analysis and late-life depression.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2008-3-19 en_US
duke.description.endpage e1837 en_US
duke.description.issue 3 en_US
duke.description.startpage e1837 en_US
duke.description.volume 3 en_US
dc.relation.journal Plos One en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/18350172
pubs.issue 3
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Psychiatry & Behavioral Sciences
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Psychiatry & Behavioral Sciences/Psychiatry & Behavioral Sciences, Geriatric Behavioral Health
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Psychiatry & Behavioral Sciences/Psychiatry & Behavioral Sciences, Translational Neuroscience
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Radiology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke-UNC Center for Brain Imaging and Analysis
pubs.publication-status Published online
pubs.volume 3
dc.identifier.eissn 1932-6203

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