Show simple item record

dc.contributor.author Cai, Xinjiang en_US
dc.date.accessioned 2011-06-21T17:31:25Z
dc.date.available 2011-06-21T17:31:25Z
dc.date.issued 2008 en_US
dc.identifier.citation Cai,Xinjiang;Clapham,David E.. 2008. Evolutionary Genomics Reveals Lineage-Specific Gene Loss and Rapid Evolution of a Sperm-Specific Ion Channel Complex: CatSpers and CatSper beta. Plos One 3(10): e3569-e3569. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://hdl.handle.net/10161/4505
dc.description.abstract The mammalian CatSper ion channel family consists of four sperm-specific voltage-gated Ca2+ channels that are crucial for sperm hyperactivation and male fertility. All four CatSper subunits are believed to assemble into a heteromultimeric channel complex, together with an auxiliary subunit, CatSperb. Here, we report a comprehensive comparative genomics study and evolutionary analysis of CatSpers and CatSperb, with important correlation to physiological significance of molecular evolution of the CatSper channel complex. The development of the CatSper channel complex with four CatSpers and CatSperb originated as early as primitive metazoans such as the Cnidarian Nematostella vectensis. Comparative genomics revealed extensive lineage-specific gene loss of all four CatSpers and CatSperb through metazoan evolution, especially in vertebrates. The CatSper channel complex underwent rapid evolution and functional divergence, while distinct evolutionary constraints appear to have acted on different domains and specific sites of the four CatSper genes. These results reveal unique evolutionary characteristics of sperm-specific Ca2+ channels and their adaptation to sperm biology through metazoan evolution. en_US
dc.language.iso en_US en_US
dc.publisher PUBLIC LIBRARY SCIENCE en_US
dc.relation.isversionof doi:10.1371/journal.pone.0003569 en_US
dc.subject biology en_US
dc.subject multidisciplinary sciences en_US
dc.title Evolutionary Genomics Reveals Lineage-Specific Gene Loss and Rapid Evolution of a Sperm-Specific Ion Channel Complex: CatSpers and CatSper beta en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US
duke.date.pubdate 2008-10-30 en_US
duke.description.endpage e3569 en_US
duke.description.issue 10 en_US
duke.description.startpage e3569 en_US
duke.description.volume 3 en_US
dc.relation.journal Plos One en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record