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dc.contributor.author Watson, KK
dc.contributor.author Ghodasra, JH
dc.contributor.author Platt, ML
dc.date.accessioned 2011-06-21T17:31:26Z
dc.date.issued 2009
dc.identifier.citation PLoS ONE, 2009, 4 (1)
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10161/4511
dc.description.abstract Background: Serotonin signaling influences social behavior in both human and nonhuman primates. In humans, variation upstream of the promoter region of the serotonin transporter gene (5-HTTLPR) has recently been shown to influence both behavioral measures of social anxiety and amygdala response to social threats. Here we show that length polymorphisms in 5-HTTLPR predict social reward and punishment in rhesus macaques, a species in which 5-HTTLPR variation is analogous to that of humans. Methodology/Principal Findings: In contrast to monkeys with two copies of the long allele (L/L), monkeys with one copy of the short allele of this gene (S/L) spent less time gazing at face than non-face images, less time looking in the eye region of faces, and had larger pupil diameters when gazing at photos of a high versus low status male macaques. Moreover, in a novel primed gambling task, presentation of photos of high status male macaques promoted risk-aversion in S/L monkeys but promoted risk-seeking in L/L monkeys. Finally, as measured by a "pay-per-view" task, S/L monkeys required juice payment to view photos of high status males, whereas L/L monkeys sacrificed fluid to see the same photos. Conclusions/Significance: These data indicate that genetic variation in serotonin function contributes to social reward and punishment in rhesus macaques, and thus shapes social behavior in humans and rhesus macaques alike. © 2009 Watson et al.
dc.language.iso en_US en_US
dc.relation.ispartof PLoS ONE
dc.relation.isversionof 10.1371/journal.pone.0004156
dc.title Serotonin transporter genotype modulates social reward and punishment in rhesus macaques
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2009-1-14 en_US
duke.description.endpage e4156 en_US
duke.description.issue 1 en_US
duke.description.startpage e4156 en_US
duke.description.volume 4 en_US
dc.relation.journal Plos One en_US
pubs.issue 1
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Neurobiology
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Evolutionary Anthropology
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Psychology and Neuroscience
pubs.volume 4

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