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dc.contributor.author Chen, EL
dc.contributor.author Kim, RJ
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:31:27Z
dc.date.issued 2010-01-05
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20052404
dc.identifier.citation PLoS One, 2010, 5 (1), pp. e8565 - ?
dc.identifier.uri http://hdl.handle.net/10161/4518
dc.description.abstract BACKGROUND: Image contrast in clinical MRI is often determined by differences in tissue water proton relaxation behavior. However, many aspects of water proton relaxation in complex biological media, such as protein solutions and tissue are not well understood, perhaps due to the limited empirical data. PRINCIPAL FINDINGS: Water proton T(1), T(2), and T(1rho) of protein solutions and tissue were measured systematically under multiple conditions. Crosslinking or aggregation of protein decreased T(2) and T(1rho), but did not change high-field T(1). T(1rho) dispersion profiles were similar for crosslinked protein solutions, myocardial tissue, and cartilage, and exhibited power law behavior with T(1rho)(0) values that closely approximated T(2). The T(1rho) dispersion of mobile protein solutions was flat above 5 kHz, but showed a steep curve below 5 kHz that was sensitive to changes in pH. The T(1rho) dispersion of crosslinked BSA and cartilage in DMSO solvent closely resembled that of water solvent above 5 kHz but showed decreased dispersion below 5 kHz. CONCLUSIONS: Proton exchange is a minor pathway for tissue T(1) and T(1rho) relaxation above 5 kHz. Potential models for relaxation are discussed, however the same molecular mechanism appears to be responsible across 5 decades of frequencies from T(1rho) to T(1).
dc.format.extent e8565 - ?
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0008565
dc.subject Animals
dc.subject Electrophoresis, Polyacrylamide Gel
dc.subject Hydrogen-Ion Concentration
dc.subject Magnetic Resonance Imaging
dc.subject Models, Theoretical
dc.subject Proteins
dc.subject Protons
dc.subject Rabbits
dc.subject Rats
dc.subject Rats, Sprague-Dawley
dc.subject Water
dc.title Magnetic resonance water proton relaxation in protein solutions and tissue: T(1rho) dispersion characterization.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-1-5 en_US
duke.description.endpage e8565 en_US
duke.description.issue 1 en_US
duke.description.startpage e8565 en_US
duke.description.volume 5 en_US
dc.relation.journal Plos One en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20052404
pubs.issue 1
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Cardiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Radiology
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 1932-6203

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