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dc.contributor.author Bennett, SM
dc.contributor.author Mercer, JM
dc.contributor.author Noor, MAF
dc.date.accessioned 2011-06-21T17:31:31Z
dc.date.issued 2010
dc.identifier.citation PLoS ONE, 2010, 5 (6)
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10161/4545
dc.description.abstract Several recent studies have examined the function and evolution of a Drosophila homolog to the human breast cancer susceptibility gene BRCA2, named dmbrca2. We previously identified what appeared to be a recent expansion in the RAD51-binding BRC-repeat array in the ancestor of Drosophila yakuba. In this study, we examine patterns of variation and evolution of the dmbrca2 BRC-repeat array within D. yakuba and its close relatives. We develop a model of how unequal crossing over may have produced the expanded form, but we also observe short repeat forms, typical of other species in the D. melanogaster group, segregating within D. yakuba and D. santomea. These short forms do not appear to be identical-by-descent, suggesting that the history of dmbrca2 in the D. melanogaster subgroup has involved repeat unit contractions resulting in homoplasious forms. We conclude that the evolutionary history of dmbrca2 in D. yakuba and perhaps in other Drosophila species may be more complicated than can be inferred from examination of the published single genome sequences per species. © 2010 Bennett et al.
dc.language.iso en_US en_US
dc.relation.ispartof PLoS ONE
dc.relation.isversionof 10.1371/journal.pone.0011006
dc.title Slip-sliding away: Serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-6-8 en_US
duke.description.endpage e11006 en_US
duke.description.issue 6 en_US
duke.description.startpage e11006 en_US
duke.description.volume 5 en_US
dc.relation.journal Plos One en_US
pubs.issue 6
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Biology
pubs.volume 5

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