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dc.contributor.advisor Clark, Robert L en_US
dc.contributor.advisor Cole, Daniel G en_US
dc.contributor.author Wulff, Kurt D en_US
dc.date.accessioned 2008-01-02T16:33:41Z
dc.date.available 2008-01-02T16:33:41Z
dc.date.issued 2007-12-13 en_US
dc.identifier.uri http://hdl.handle.net/10161/454
dc.description Dissertation en_US
dc.description.abstract This research presents the development of an advanced, state-of-the-art optical trap for use in biological materials and nanosystems investigation. An optical trap is an instrument capable of manipulating microscopic particles using the inherent momentum of light. First introduced by Askin et al., the single beam gradient optical trap is capable of generating small forces (~1-100 pN) in a noninvasive manner. As a result, the optical trap is often used to manipulate biological specimen. This research presents the process for the construction of a custom optical trap, the methods to build a controllable optical trap through a traditional fixed gain controller as well as an adaptive controller, and also enables the application of torque to trapped particles. A method of using adaptive techniques for system identification and calibration is also presented. This research has the potential to use forces and torques to affect our understanding of the mechanics of single molecules and motor proteins. This instrument provides a more precise means of manipulating biological specimen as well as a tool for nanofabrication and has the potential to expand the knowledge base of DNA, chromosomes, biomotors, motor proteins, reversible polymers, and can be used to control chemical reactions. The research presented here documents the creation of an optical trap that is sensitive for applications requiring precise displacements and forces, adaptable to a variety of current and future research applications, and useable by anyone interested in researching micro- and nanosytems. en_US
dc.format.extent 8902776 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.subject Engineering, Mechanical en_US
dc.subject Physics, Optics en_US
dc.subject optical tweezer en_US
dc.subject optical trap en_US
dc.title Adaptive Control of an Optical Trap for Single Molecule and Motor Protein Research en_US
dc.type Dissertation en_US
dc.department Mechanical Engineering and Materials Science en_US

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