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dc.contributor.author Van Houtan, Kyle en_US
dc.date.accessioned 2011-06-21T17:32:14Z
dc.date.available 2011-06-21T17:32:14Z
dc.date.issued 2010 en_US
dc.identifier.citation Van Houtan,Kyle S.;Hargrove,Stacy K.;Balazs,George H.. 2010. Land Use, Macroalgae, and a Tumor-Forming Disease in Marine Turtles. Plos One 5(9): e12900-e12900. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://hdl.handle.net/10161/4572
dc.description.abstract Wildlife diseases are an increasing concern for endangered species conservation, but their occurrence, causes, and human influences are often unknown. We analyzed 3,939 records of stranded Hawaiian green sea turtles (Chelonia mydas) over 28 years to understand fibropapillomatosis, a tumor-forming disease linked to a herpesvirus. Turtle size is a consistent risk factor and size-standardized models revealed considerable spatial and temporal variability. The disease peaked in some areas in the 1990s, in some regions rates remained constant, and elsewhere rates increased. Land use, onshore of where the turtles feed, may play a role. Elevated disease rates were clustered in watersheds with high nitrogen-footprints; an index of natural and anthropogenic factors that affect coastal eutrophication. Further analysis shows strong epidemiological links between disease rates, nitrogen-footprints, and invasive macroalgae and points to foraging ecology. These turtles now forage on invasive macroalgae, which can dominate nutrient rich waters and sequester environmental N in the amino acid arginine. Arginine is known to regulate immune activity, promote herpesviruses, and contribute to tumor formation. Our results have implications for understanding diseases in aquatic organisms, eutrophication, herpesviruses, and tumor formation. en_US
dc.language.iso en_US en_US
dc.publisher PUBLIC LIBRARY SCIENCE en_US
dc.relation.isversionof doi:10.1371/journal.pone.0012900 en_US
dc.subject green sea-turtles en_US
dc.subject chelonia-mydas en_US
dc.subject hawaiian-islands en_US
dc.subject somatic growth en_US
dc.subject fibropapillomatosis en_US
dc.subject arginine en_US
dc.subject virus en_US
dc.subject herpesvirus en_US
dc.subject infection en_US
dc.subject region en_US
dc.subject biology en_US
dc.subject multidisciplinary sciences en_US
dc.title Land Use, Macroalgae, and a Tumor-Forming Disease in Marine Turtles en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US
duke.date.pubdate 2010-9-29 en_US
duke.description.endpage e12900 en_US
duke.description.issue 9 en_US
duke.description.startpage e12900 en_US
duke.description.volume 5 en_US
dc.relation.journal Plos One en_US

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