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dc.contributor.author Feng, J
dc.contributor.author Wang, QS
dc.contributor.author Chiang, A
dc.contributor.author Chen, BY
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:32:16Z
dc.date.issued 2010
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20949089
dc.identifier.citation PLoS One, 2010, 5 (10), pp. e13201 - ?
dc.identifier.uri http://hdl.handle.net/10161/4574
dc.description.abstract OBJECTIVES: To develop a sleep hypoxia (SH) in emphysema (SHE) rat model and to explore whether SHE results in more severe hepatic inflammation than emphysema alone and whether the inflammation changes levels of coagulant/anticoagulant factors synthesized in the liver. METHODS: Seventy-five rats were put into 5 groups: SH control (SHCtrl), treated with sham smoke exposure (16 weeks) and SH exposure (12.5% O(2), 3 h/d, latter 8 weeks); emphysema control (ECtrl), smoke exposure and sham SH exposure (21% O(2)); short SHE (SHEShort), smoke exposure and short SH exposure (1.5 h/d); mild SHE (SHEMild), smoke exposure and mild SH exposure (15% O(2)); standard SHE (SHEStand), smoke exposure and SH exposure. Therefore, ECtrl, SHEShort, SHEMild and SHEStand group were among emphysematous groups. Arterial blood gas (ABG) data was obtained during preliminary tests. After exposure, hepatic inflammation (interleukin -6 [IL-6] mRNA and protein, tumor necrosis factor α [TNFα] mRNA and protein) and liver coagulant/anticoagulant factors (antithrombin [AT], fibrinogen [FIB] and Factor VIII [F VIII]) were evaluated. SPSS 11.5 software was used for statistical analysis. RESULTS: Characteristics of emphysema were obvious in emphysematous groups and ABGs reached SH criteria on hypoxia exposure. Hepatic inflammation parameters and coagulant factors are the lowest in SHCtrl and the highest in SHEStand while AT is the highest in SHCtrl and the lowest in SHEStand. Inflammatory cytokines of liver correlate well with coagulant factors positively and with AT negatively. CONCLUSIONS: When SH is combined with emphysema, hepatic inflammation and coagulability enhance each other synergistically and produce a more significant liver-derivative inflammatory and prothrombotic status.
dc.format.extent e13201 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0013201
dc.subject Animals
dc.subject Anoxia
dc.subject Base Sequence
dc.subject Coagulants
dc.subject DNA Primers
dc.subject Electroencephalography
dc.subject Emphysema
dc.subject Hepatitis, Animal
dc.subject Interleukin-6
dc.subject Male
dc.subject RNA, Messenger
dc.subject Rats
dc.subject Rats, Wistar
dc.subject Sleep
dc.subject Tumor Necrosis Factor-alpha
dc.title The effects of sleep hypoxia on coagulant factors and hepatic inflammation in emphysematous rats.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-10-6 en_US
duke.description.endpage e13201 en_US
duke.description.issue 10 en_US
duke.description.startpage e13201 en_US
duke.description.volume 5 en_US
dc.relation.journal Plos One en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20949089
pubs.issue 10
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Pulmonary, Allergy, and Critical Care Medicine
pubs.volume 5
dc.identifier.eissn 1932-6203

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