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dc.contributor.author Ribeiro, TL
dc.contributor.author Copelli, M
dc.contributor.author Caixeta, F
dc.contributor.author Belchior, H
dc.contributor.author Chialvo, DR
dc.contributor.author Nicolelis, MA
dc.contributor.author Ribeiro, S
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:32:20Z
dc.date.issued 2010-11-30
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/21152422
dc.identifier.citation PLoS One, 2010, 5 (11), pp. e14129 - ?
dc.identifier.uri http://hdl.handle.net/10161/4584
dc.description.abstract BACKGROUND: Scale-invariant neuronal avalanches have been observed in cell cultures and slices as well as anesthetized and awake brains, suggesting that the brain operates near criticality, i.e. within a narrow margin between avalanche propagation and extinction. In theory, criticality provides many desirable features for the behaving brain, optimizing computational capabilities, information transmission, sensitivity to sensory stimuli and size of memory repertoires. However, a thorough characterization of neuronal avalanches in freely-behaving (FB) animals is still missing, thus raising doubts about their relevance for brain function. METHODOLOGY/PRINCIPAL FINDINGS: To address this issue, we employed chronically implanted multielectrode arrays (MEA) to record avalanches of action potentials (spikes) from the cerebral cortex and hippocampus of 14 rats, as they spontaneously traversed the wake-sleep cycle, explored novel objects or were subjected to anesthesia (AN). We then modeled spike avalanches to evaluate the impact of sparse MEA sampling on their statistics. We found that the size distribution of spike avalanches are well fit by lognormal distributions in FB animals, and by truncated power laws in the AN group. FB data surrogation markedly decreases the tail of the distribution, i.e. spike shuffling destroys the largest avalanches. The FB data are also characterized by multiple key features compatible with criticality in the temporal domain, such as 1/f spectra and long-term correlations as measured by detrended fluctuation analysis. These signatures are very stable across waking, slow-wave sleep and rapid-eye-movement sleep, but collapse during anesthesia. Likewise, waiting time distributions obey a single scaling function during all natural behavioral states, but not during anesthesia. Results are equivalent for neuronal ensembles recorded from visual and tactile areas of the cerebral cortex, as well as the hippocampus. CONCLUSIONS/SIGNIFICANCE: Altogether, the data provide a comprehensive link between behavior and brain criticality, revealing a unique scale-invariant regime of spike avalanches across all major behaviors.
dc.format.extent e14129 - ?
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0014129
dc.subject Action Potentials
dc.subject Anesthesia
dc.subject Animals
dc.subject Brain
dc.subject Cerebral Cortex
dc.subject Hippocampus
dc.subject Male
dc.subject Models, Neurological
dc.subject Neurons
dc.subject Rats
dc.subject Rats, Long-Evans
dc.subject Sleep
dc.subject Synaptic Transmission
dc.subject Wakefulness
dc.title Spike avalanches exhibit universal dynamics across the sleep-wake cycle.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-11-30 en_US
duke.description.endpage e14129 en_US
duke.description.issue 11 en_US
duke.description.startpage e14129 en_US
duke.description.volume 5 en_US
dc.relation.journal Plos One en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/21152422
pubs.issue 11
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Neurobiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Neurology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Neurology/Neurology, Behavioral Neurology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Orthopaedics
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Psychology and Neuroscience
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 1932-6203

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