Show simple item record Chang, AS Bennett, SM Noor, MA
dc.coverage.spatial United States 2011-06-21T17:32:21Z 2010-10-27
dc.identifier.citation PLoS One, 2010, 5 (10), pp. e15377 - ?
dc.description.abstract The Bateson-Dobzhansky-Muller model posits that hybrid incompatibilities result from genetic changes that accumulate during population divergence. Indeed, much effort in recent years has been devoted to identifying genes associated with hybrid incompatibilities, often with limited success, suggesting that hybrid sterility and inviability are frequently caused by complex interactions between multiple loci and not by single or a small number of gene pairs. Our previous study showed that the nature of epistasis between sterility-conferring QTL in the Drosophila persimilis-D. pseudoobscura bogotana species pair is highly specific. Here, we further dissect one of the three QTL underlying hybrid male sterility between these species and provide evidence for multiple factors within this QTL. This result indicates that the number of loci thought to contribute to hybrid dysfunction may have been underestimated, and we discuss how linkage and complex epistasis may be characteristic of the genetics of hybrid incompatibilities. We further pinpoint the location of one locus that confers hybrid male sterility when homozygous, dubbed "mule-like", to roughly 250 kilobases.
dc.format.extent e15377 - ?
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0015377
dc.subject Animals
dc.subject Chromosome Mapping
dc.subject Drosophila
dc.subject Epistasis, Genetic
dc.subject Infertility, Male
dc.subject Male
dc.subject Quantitative Trait Loci
dc.title Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-10-27 en_US
duke.description.endpage e15377 en_US
duke.description.issue 10 en_US
duke.description.startpage e15377 en_US
duke.description.volume 5 en_US
dc.relation.journal Plos One en_US
pubs.issue 10
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Biology
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 1932-6203

Files in this item

This item appears in the following Collection(s)

Show simple item record