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dc.contributor.author Fellay, J
dc.contributor.author Shianna, KV
dc.contributor.author Telenti, A
dc.contributor.author Goldstein, DB
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:32:23Z
dc.date.issued 2010-10-14
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20976252
dc.identifier.citation PLoS Pathog, 2010, 6 (10), pp. e1001033 - ?
dc.identifier.uri http://hdl.handle.net/10161/4604
dc.description.abstract This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.
dc.format.extent e1001033 - ?
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof PLoS Pathog
dc.relation.isversionof 10.1371/journal.ppat.1001033
dc.subject Cohort Studies
dc.subject Disease Progression
dc.subject Genetic Variation
dc.subject HIV Infections
dc.subject HIV-1
dc.subject Host-Pathogen Interactions
dc.subject Humans
dc.subject Infection Control
dc.subject Models, Biological
dc.subject Treatment Outcome
dc.title Host genetics and HIV-1: the final phase?
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-10-0 en_US
duke.description.endpage e1001033 en_US
duke.description.issue 10 en_US
duke.description.startpage e1001033 en_US
duke.description.volume 6 en_US
dc.relation.journal Plos Pathogens en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20976252
pubs.issue 10
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Molecular Genetics and Microbiology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Center for Human Genome Variation
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Clinical Research Institute
pubs.publication-status Published online
pubs.volume 6
dc.identifier.eissn 1553-7374

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