Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond

dc.contributor.author	Wang, Fan	en_US
dc.date.accessioned	2011-06-21T20:18:52Z
dc.date.available	2011-06-21T20:18:52Z
dc.date.issued	2010	en_US
dc.identifier.citation	Zhou,Xiang;Wang,Fan. 2010. Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond. Autophagy 6(6): 798-799.	en_US
dc.identifier.issn	1554-8627	en_US
dc.identifier.uri	http://hdl.handle.net/10161/4636
dc.description.abstract	PIK3C3/Vps34 plays important roles in the endocytic and autophagic pathways, both of which are essential for maintaining neuronal integrity. However, it is unclear how inactivating PIK3C3 may affect neuronal endosomal versus autophagic processes in vivo. We generated a conditional null allele of the Pik3c3 gene in mouse, and specifically deleted it in postmitotic sensory neurons. Subsequent analyses reveal several interesting and surprising findings.	en_US
dc.language.iso	en_US	en_US
dc.publisher	LANDES BIOSCIENCE	en_US
dc.relation.isversionof		en_US
dc.subject	pik3c3/vps34	en_US
dc.subject	atg7	en_US
dc.subject	sensory neurons	en_US
dc.subject	neurodegeneration	en_US
dc.subject	autophagy	en_US
dc.subject	abnormal endosome	en_US
dc.subject	cell biology	en_US
dc.title	Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond	en_US
dc.title.alternative		en_US
dc.description.version	Version of Record	en_US
duke.date.pubdate	2010-8-16	en_US
duke.description.endpage	799	en_US
duke.description.issue	6	en_US
duke.description.startpage	798	en_US
duke.description.volume	6	en_US
dc.relation.journal	Autophagy	en_US