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dc.contributor.advisor Nijhout, H. Frederik en_US
dc.contributor.author Callier, Viviane en_US
dc.date.accessioned 2012-01-10T15:57:55Z
dc.date.available 2013-12-30T05:30:08Z
dc.date.issued 2011 en_US
dc.identifier.uri http://hdl.handle.net/10161/4967
dc.description Dissertation en_US
dc.description.abstract <p>The regulation of body size is one of the fundamental unsolved problems in developmental biology. The control of body size requires a mechanism that assesses size and stops growth when a characteristic size is reached. In Manduca sexta the endocrine events that lead to a molt start when the larva reaches a critical weight. Molting is initiated by a size-sensing mechanism, but the nature of this mechanism has remained elusive. Here I show that this size sensing mechanism emerges from the changing relationship between the increasing body mass and the fixed tracheal system in each instar. As body mass increases, the demand for oxygen also increases, but the fixed tracheal system does not allow a corresponding increase in oxygen supply. Low oxygen tension reduces this critical weight and induces molting at smaller body size. Body size is regulated by a mechanism that senses oxygen limitation and triggers the endocrine events that lead to molting and metamorphosis.</p> en_US
dc.subject Physiology en_US
dc.subject Developmental biology en_US
dc.subject body size en_US
dc.subject critical weight en_US
dc.subject oxygen en_US
dc.subject trachea en_US
dc.title Respiratory physiology and the initiation of molting in the tobacco hornworm, Manduca sexta en_US
dc.type Dissertation en_US
dc.department Biology en_US
duke.embargo.months 24 en_US

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