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dc.contributor.author Kang, Y
dc.contributor.author Chen, BJ
dc.contributor.author Deoliveira, D
dc.contributor.author Mito, J
dc.contributor.author Chao, NJ
dc.coverage.spatial United States
dc.date.accessioned 2012-01-20T16:02:17Z
dc.date.issued 2010
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20596257
dc.identifier.citation PLoS One, 2010, 5 (6), pp. e11316 - ?
dc.identifier.uri http://hdl.handle.net/10161/5087
dc.description.abstract The interaction between stromal cell-derived factor-1 (SDF-1) with CXCR4 chemokine receptors plays an important role in hematopoiesis following hematopoietic stem cell transplantation. We examined the efficacy of post transplant administration of a specific CXCR4 antagonist (AMD3100) in improving animal survival and in enhancing donor hematopoietic cell engraftment using a congeneic mouse transplantation model. AMD3100 was administered subcutaneously at 5 mg/kg body weight 3 times a week beginning at day +2 post-transplant. Post-transplant administration of AMD3100 significantly improves animal survival. AMD3100 reduces pro-inflammatory cytokine/chemokine production. Furthermore, post transplant administration of AMD3100 selectively enhances donor cell engraftment and promotes recovery of all donor cell lineages (myeloid cells, T and B lymphocytes, erythrocytes and platelets). This enhancement results from a combined effect of increased marrow niche availability and greater cell division induced by AMD3100. Our studies shed new lights into the biological roles of SDF-1/CXCR4 interaction in hematopoietic stem cell engraftment following transplantation and in transplant-related mortality. Our results indicate that AMD3100 provides a novel approach for enhancing hematological recovery following transplantation, and will likely benefit patients undergoing transplantation.
dc.format.extent e11316 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0011316
dc.subject Animals
dc.subject Cytokines
dc.subject Hematopoietic Stem Cell Transplantation
dc.subject Hematopoietic Stem Cells
dc.subject Heterocyclic Compounds
dc.subject Mice
dc.subject Receptors, CXCR4
dc.title Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model.
dc.type Journal Article
duke.description.endpage 14 en_US
duke.description.issue 6 en_US
duke.description.startpage 1 en_US
duke.description.volume 5 en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20596257
pubs.issue 6
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Immunology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Cellular Therapy
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/University Institutes and Centers
pubs.organisational-group /Duke/University Institutes and Centers/Global Health Institute
pubs.volume 5
dc.identifier.eissn 1932-6203

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