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dc.contributor.author Hwang, RY
dc.contributor.author Gauthier, DJ
dc.contributor.author Wallace, D
dc.contributor.author Afshari, NA
dc.coverage.spatial United States
dc.date.accessioned 2012-02-13T20:02:39Z
dc.date.issued 2011-02-22
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/21051729
dc.identifier iovs.10-5839
dc.identifier.citation Invest Ophthalmol Vis Sci, 2011, 52 (2), pp. 1043 - 1054
dc.identifier.uri http://hdl.handle.net/10161/5106
dc.description.abstract PURPOSE: To develop a mathematical model that can predict refractive changes after Descemet stripping endothelial keratoplasty (DSEK). METHODS: A mathematical formula based on the Gullstrand eye model was generated to estimate the change in refractive power of the eye after DSEK. This model was applied to four DSEK cases retrospectively, to compare measured and predicted refractive changes after DSEK. RESULTS: The refractive change after DSEK is determined by calculating the difference in the power of the eye before and after DSEK surgery. The power of the eye post-DSEK surgery can be calculated with modified Gullstrand eye model equations that incorporate the change in the posterior radius of curvature and change in the distance between the principal planes of the cornea and lens after DSEK. Analysis of this model suggests that the ratio of central to peripheral graft thickness (CP ratio) and central thickness can have significant effect on refractive change where smaller CP ratios and larger graft thicknesses result in larger hyperopic shifts. This model was applied to four patients, and the average predicted hyperopic shift in the overall power of the eye was calculated to be 0.83 D. This change reflected in a mean of 93% (range, 75%-110%) of patients' measured refractive shifts. CONCLUSIONS: This simplified DSEK mathematical model can be used as a first step for estimating the hyperopic shift after DSEK. Further studies are necessary to refine the validity of this model.
dc.format.extent 1043 - 1054
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof Invest Ophthalmol Vis Sci
dc.relation.isversionof 10.1167/iovs.10-5839
dc.subject Cornea
dc.subject Descemet Stripping Endothelial Keratoplasty
dc.subject Fuchs' Endothelial Dystrophy
dc.subject Humans
dc.subject Hyperopia
dc.subject Models, Theoretical
dc.subject Refraction, Ocular
dc.subject Retrospective Studies
dc.title Refractive changes after descemet stripping endothelial keratoplasty: a simplified mathematical model.
dc.type Journal Article
duke.description.endpage 1054 en_US
duke.description.issue 5 en_US
duke.description.startpage 1043 en_US
duke.description.volume 52 en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/21051729
pubs.issue 2
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Electrical and Computer Engineering
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Physics
pubs.publication-status Published online
pubs.volume 52
dc.identifier.eissn 1552-5783

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