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dc.contributor.advisor Noor, Mohamed A.F. en_US
dc.contributor.author McDermott, Shannon en_US
dc.date.accessioned 2012-05-25T20:07:45Z
dc.date.available 2012-05-25T20:07:45Z
dc.date.issued 2012 en_US
dc.identifier.uri http://hdl.handle.net/10161/5416
dc.description Dissertation en_US
dc.description.abstract <p>Speciation has occurred countless times throughout history, and yet the genetic mechanisms that lead to speciation are still missing pieces. Here, we describe the genetics of two processes that can act alone or together to cause speciation: hybrid sterility and meiotic drive. We use the <italic>Drosophila pseudoobscura/D, persimilis</italic> species as a model system to study these processes. We expanded on a prior study and saw little variation in strength of previously known hybrid sterility alleles between distinct strains of <italic>D. persimilis</italic> and the Bogota subspecies of <italic>D. pseudoobscura</italic>. Introgression of an autosomal, noninverted hybrid sterility allele from the USA subspecies of <italic>D. pseudoobscura</italic> into <italic>D. persimilis</italic> demonstrated that the <italic>D. pseudoobscura</italic> copy of a <italic>D. persimilis</italic> hybrid sterility factor also causes hybrid male sterility in a <italic>D. pseudoobscura bogotana</italic> background. This allelism suggests that the introgressed allele is ancestral, but was lost in the Bogota lineage, or that gene flow between <italic>D. pseudoobscura</italic> USA and <italic>D. persimilis</italic> moved the sterility-conferring allele from <italic>D. persimilis</italic> into <italic>D. pseudoobscura</italic>. To further understand the genetic basis of speciation, we asked if meiotic drive in <italic>D. persimilis</italic> is associated with hybrid sterility seen in <italic>D. persimilis/D. pseudoobscura</italic> hybrids. QTL mapping of both traits along the right arm of the X chromosome, where both drive and hybrid sterility loci are found, suggest that some of the causal loci overlap and may be allelic.</p> en_US
dc.subject Genetics en_US
dc.subject Evolution & development en_US
dc.subject Drosophila en_US
dc.subject Hybrid Sterility en_US
dc.subject Meiotic Drive en_US
dc.subject Segregation Distortion en_US
dc.subject Speciation en_US
dc.title Hybrid Sterility and Segregation Distortion in Drosophila pseudoobscura and Drosophila persimilis en_US
dc.type Dissertation en_US
dc.department Genetics and Genomics en_US

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