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dc.contributor.advisor West, Anne en_US
dc.contributor.author Lyons, MR
dc.contributor.author West, AE
dc.coverage.spatial England
dc.date.accessioned 2012-05-25T20:08:42Z
dc.date.issued 2011-08
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/21620929
dc.identifier S0301-0082(11)00074-8
dc.identifier.citation Prog Neurobiol, 2011, 94 (3), pp. 259 - 295
dc.identifier.uri http://hdl.handle.net/10161/5425
dc.description Dissertation en_US
dc.description.abstract The brain is a highly adaptable organ that is capable of converting sensory information into changes in neuronal function. This plasticity allows behavior to be accommodated to the environment, providing an important evolutionary advantage. Neurons convert environmental stimuli into long-lasting changes in their physiology in part through the synaptic activity-regulated transcription of new gene products. Since the neurotransmitter-dependent regulation of Fos transcription was first discovered nearly 25 years ago, a wealth of studies have enriched our understanding of the molecular pathways that mediate activity-regulated changes in gene transcription. These findings show that a broad range of signaling pathways and transcriptional regulators can be engaged by neuronal activity to sculpt complex programs of stimulus-regulated gene transcription. However, the shear scope of the transcriptional pathways engaged by neuronal activity raises the question of how specificity in the nature of the transcriptional response is achieved in order to encode physiologically relevant responses to divergent stimuli. Here we summarize the general paradigms by which neuronal activity regulates transcription while focusing on the molecular mechanisms that confer differential stimulus-, cell-type-, and developmental-specificity upon activity-regulated programs of neuronal gene transcription. In addition, we preview some of the new technologies that will advance our future understanding of the mechanisms and consequences of activity-regulated gene transcription in the brain.
dc.format.extent 259 - 295
dc.language eng
dc.relation.ispartof Prog Neurobiol
dc.relation.isversionof 10.1016/j.pneurobio.2011.05.003
dc.subject Animals
dc.subject Brain-Derived Neurotrophic Factor
dc.subject Chromatin
dc.subject Gene Expression Profiling
dc.subject Gene Expression Regulation
dc.subject Histones
dc.subject Humans
dc.subject Neuronal Plasticity
dc.subject Neurons
dc.subject Promoter Regions, Genetic
dc.subject RNA Interference
dc.subject Receptors, N-Methyl-D-Aspartate
dc.subject Transcription Factors
dc.subject Transcription, Genetic
dc.title Mechanisms of specificity in neuronal activity-regulated gene transcription.
dc.type Journal Article
dc.department Neurobiology en_US
duke.embargo.months 24 en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/21620929
pubs.issue 3
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Neurobiology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.publication-status Published
pubs.volume 94
dc.identifier.eissn 1873-5118

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