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dc.contributor.advisor Badea, Cristian T en_US
dc.contributor.author Johnston, Samuel Morris en_US
dc.date.accessioned 2012-05-25T20:21:05Z
dc.date.available 2013-05-20T04:30:06Z
dc.date.issued 2012 en_US
dc.identifier.uri http://hdl.handle.net/10161/5589
dc.description Dissertation en_US
dc.description.abstract <p>X-ray micro-CT is widely used for small animal imaging in preclinical studies of cardiopulmonary disease, but further development is needed to improve spatial resolution, temporal resolution, and material contrast. This study presents a set of tools that achieve these improvements. These tools include the mathematical formulation and computational implementation of algorithms for calibration, image reconstruction, and image analysis with our custom micro-CT system. These tools are tested in simulations and in experiments with live animals. With these tools, it is possible to visualize the distribution of a contrast agent throughout the body of a mouse as it changes over time, and produce 5-dimensional images (3 spatial dimensions + time + energy) of the cardiac cycle.</p> en_US
dc.subject Medical imaging and radiology en_US
dc.subject Biomedical engineering en_US
dc.subject Computer science en_US
dc.subject calibration en_US
dc.subject reconstruction en_US
dc.subject small animal en_US
dc.subject spectral en_US
dc.subject temporal en_US
dc.subject X-ray CT en_US
dc.title Strategies for Temporal and Spectral Imaging with X-ray Computed Tomography en_US
dc.type Dissertation en_US
dc.department Biomedical Engineering en_US
duke.embargo.months 12 en_US

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