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dc.contributor.advisor Warren, Warren S en_US
dc.contributor.author Reese, Rachel en_US
dc.date.accessioned 2012-05-29T16:37:34Z
dc.date.available 2014-05-19T04:30:04Z
dc.date.issued 2011 en_US
dc.identifier.uri http://hdl.handle.net/10161/5622
dc.description Thesis en_US
dc.description.abstract <p>For women with a high risk of developing breast cancer, the treatment options can be drastic, unnecessary, and emotionally and physically scarring. While histological evaluation of tissue samples is reliable for invasive breast cancers, the malignant potential from ductal carcinoma in situ (DCIS) cannot be reliably predicted from histopathology. Biomarkers in the breast have appeal as being directly reflective of underlying preneoplastic processes and could be used to accurately predict short-term breast cancer risk even in DCIS. By using 1H NMR metabonomics on interstitial breast fluid provided from random periareaolar fine-needle aspirations, as well as wash fluid from breast extractions, some potential biomarkers have been uncovered that could aid physicians in the prognosis of high-risk women.</p> en_US
dc.subject Chemistry en_US
dc.title Exploring Breast Cancer Risk Using NMR Metabonomics: Interstitial Breast Fluid and Breast Cancer Biomarkers en_US
dc.type Thesis en_US
dc.department Chemistry en_US
duke.embargo.months 24 en_US

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