Show simple item record

dc.contributor.advisor Shah, Svati en_US
dc.contributor.author Lam, Christopher Thy en_US
dc.date.accessioned 2012-09-04T13:17:29Z
dc.date.available 2013-08-30T04:30:05Z
dc.date.issued 2012 en_US
dc.identifier.uri http://hdl.handle.net/10161/5859
dc.description Thesis en_US
dc.description.abstract <p>The burden of hypertension and subsequent in Tibet is quite profound and disproportionate when compared to other Chinese populations. Thus, there has a recent impetus to focus on low-cost sustainable health interventions to ameliorate this tremendous burden. Factors of compliance of first-line low dose hypertensive medications are not known in semi-nomadic Tibetan herdsmen at high altitude.</p><p>A retrospective analysis of a de-identified database for a single blinded equal allocation randomized control trial for a dietary reduced sodium salt substitute completed in 2009 using STATA 11.2 (STATA INC. College Station, TX) and logistic regression was performed. Patients were recruited from two townships at 4300 m altitude and northwest of Lhasa, the regional capital. Eligibility criteria included: age 40 years and older, with hypertension (&#8805; 140mmHg / &#8805; 90 mmHg) , enrollment in salt substitute trial, and prescription of hypertensive medication. Primary outcome was compliance to medication at three and six months of follow-up. Factor variables included and adjusted for included: sex, age, blood pressure, township, class of medication, and trial arm assignment.</p><p>The overall rate of non-compliance was 33.0% (38/115) after three months and 12.9% (28/217) after six months. After three months follow-up patients with Stage I and Stage II hypertension were at an adjusted odds ratio of 0.03(95%CI: 0.002-0.70) and 0.13(95%CI: 0.012-1.37) times lower odds of non-compliance when compared patients with only isolated systolic hypertension, (p=0.028 and 0.089, respectively). Furthermore, at six months of follow-up patients prescribed combination pharmacologic therapy had an adjusted odds ratios of 0.20 (95%CI: 0.05-0.81) times lower odds than those patients on diuretic only, p =0.023.</p> en_US
dc.subject Medicine en_US
dc.subject Public health en_US
dc.subject ACE Inhibitor en_US
dc.subject Compliance en_US
dc.subject Hypertension en_US
dc.subject Salt Substitute en_US
dc.subject Thiazide Diuretic en_US
dc.subject Tibet en_US
dc.title Compliance of First-Line Anti-Hypertensive Medications in Elderly Tibetan Semi-Nomadic Pastoralists en_US
dc.type Thesis en_US
dc.department Global Health en_US
duke.embargo.months 12 en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record