Bacterial vaginosis as a risk factor for high-grade cervical lesions and cancer in HIV-seropositive women

Abstract

Objective: To assess the effect of bacterial vaginosis (BV) on the risk of high-grade squamous intraepithelial lesions (HSIL) among HIV-seropositive women. Methods: A hospital-based prospective cohort study of HIV-seropositive women was conducted in Johannesburg, South Africa from January 2005 to September 2009. Multivariate log-binomial and Poisson regressions were used to estimate prevalence and rate ratios, respectively. Results: Among 1954 HIV-seropositive women, the baseline prevalence of HSIL was 17%. BV prevalence was high (54%) and showed no association with prevalence of HSIL (adjusted prevalence ratio, 1.12; 95% confidence intervals (CI), 0.92–1.35) nor with cervical lesion progression at follow-up visit (n = 503) (adjusted rate ratio: 1.00; 95% CI, 0.65–1.53). Conclusion: Among HIV-seropositive women, BV was not associated with an increased risk of HSIL or cervical lesion progression.