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dc.contributor.author Hall, RA
dc.contributor.author Lefkowitz, RJ
dc.coverage.spatial United States
dc.date.accessioned 2012-10-23T22:04:16Z
dc.date.issued 2002-10-18
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/12386143
dc.identifier.citation Circ Res, 2002, 91 (8), pp. 672 - 680
dc.identifier.uri http://hdl.handle.net/10161/5917
dc.description.abstract The actions of many hormones and neurotransmitters are mediated through stimulation of G protein-coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with heterotrimeric G proteins, which can activate a wide variety of cellular enzymes and ion channels. G protein-coupled receptors can also interact with a number of cytoplasmic scaffold proteins, which can link the receptors to various signaling intermediates and intracellular effectors. The multicomponent nature of G protein-coupled receptor signaling pathways makes them ideally suited for regulation by scaffold proteins. This review focuses on several specific examples of G protein-coupled receptor-associated scaffolds and the roles they may play in organizing receptor-initiated signaling pathways in the cardiovascular system and other tissues.
dc.format.extent 672 - 680
dc.language eng
dc.relation.ispartof Circ Res
dc.subject Animals
dc.subject Arrestins
dc.subject Heterotrimeric GTP-Binding Proteins
dc.subject Macromolecular Substances
dc.subject Models, Biological
dc.subject Myocardium
dc.subject Proteins
dc.subject Receptors, Adrenergic
dc.subject Receptors, Cell Surface
dc.subject Signal Transduction
dc.title Regulation of G protein-coupled receptor signaling by scaffold proteins.
dc.type Journal Article
duke.description.endpage 680 en_US
duke.description.issue 8 en_US
duke.description.startpage 672 en_US
duke.description.volume 91 en_US
dc.relation.journal Circulation Research en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/12386143
pubs.issue 8
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Biochemistry
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Cardiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Chemistry
pubs.publication-status Published
pubs.volume 91
dc.identifier.eissn 1524-4571

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