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dc.contributor.author Vidal, AC
dc.contributor.author Murphy, SK
dc.contributor.author Hernandez, BY
dc.contributor.author Vasquez, B
dc.contributor.author Bartlett, JA
dc.contributor.author Oneko, O
dc.contributor.author Mlay, P
dc.contributor.author Obure, J
dc.contributor.author Overcash, F
dc.contributor.author Smith, JS
dc.contributor.author van der Kolk, M
dc.contributor.author Hoyo, C
dc.coverage.spatial England
dc.date.accessioned 2012-10-25T20:43:59Z
dc.date.issued 2011-11-14
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/22081870
dc.identifier 1750-9378-6-20
dc.identifier.citation Infect Agent Cancer, 2011, 6 (1), pp. 20 - ?
dc.identifier.uri http://hdl.handle.net/10161/5939
dc.description.abstract BACKGROUND: Infection with human papillomavirus (HPV) is associated with uterine cervical intraepithelial neoplasia (CIN) and invasive cancers (ICC). Approximately 80% of ICC cases are diagnosed in under-developed countries. Vaccine development relies on knowledge of HPV genotypes characteristic of LSIL, HSIL and cancer; however, these genotypes remain poorly characterized in many African countries. To contribute to the characterization of HPV genotypes in Northeastern Tanzania, we recruited 215 women from the Reproductive Health Clinic at Kilimanjaro Christian Medical Centre. Cervical scrapes and biopsies were obtained for cytology and HPV DNA detection. RESULTS: 79 out of 215 (36.7%) enrolled participants tested positive for HPV DNA, with a large proportion being multiple infections (74%). The prevalence of HPV infection increased with lesion grade (14% in controls, 67% in CIN1 cases and 88% in CIN2-3). Among ICC cases, 89% had detectable HPV. Overall, 31 HPV genotypes were detected; the three most common HPV genotypes among ICC were HPV16, 35 and 45. In addition to these genotypes, co-infection with HPV18, 31, 33, 52, 58, 68 and 82 was found in 91% of ICC. Among women with CIN2-3, HPV53, 58 and 84/83 were the most common. HPV35, 45, 53/58/59 were the most common among CIN1 cases. CONCLUSIONS: In women with no evidence of cytological abnormalities, the most prevalent genotypes were HPV58 with HPV16, 35, 52, 66 and 73 occurring equally. Although numerical constraints limit inference, findings that 91% of ICC harbor only a small number of HPV genotypes suggests that prevention efforts including vaccine development or adjuvant screening should focus on these genotypes.
dc.format.extent 20 - ?
dc.language eng
dc.relation.ispartof Infect Agent Cancer
dc.relation.isversionof 10.1186/1750-9378-6-20
dc.title Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women.
dc.type Journal Article
duke.description.issue 20 en_US
duke.description.volume 6 en_US
dc.relation.journal Infectious Agents and Cancer en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/22081870
pubs.issue 1
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Faculty
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/Initiatives
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/Initiatives/Duke Science & Society
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Global Health Institute
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Infectious Diseases
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Obstetrics and Gynecology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Obstetrics and Gynecology/Obstetrics and Gynecology, Gynecologic Oncology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/School of Nursing
pubs.organisational-group /Duke/School of Nursing/School of Nursing - Secondary Group
pubs.publication-status Published online
pubs.volume 6
dc.identifier.eissn 1750-9378

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