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dc.contributor.author Chang, VT
dc.contributor.author Merisier, D
dc.contributor.author Yu, B
dc.contributor.author Walmer, DK
dc.contributor.author Ramanujam, N
dc.coverage.spatial United States
dc.date.accessioned 2012-11-01T19:43:52Z
dc.date.issued 2011-09-12
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/21935155
dc.identifier 222210
dc.identifier.citation Opt Express, 2011, 19 (19), pp. 17908 - 17924
dc.identifier.uri http://hdl.handle.net/10161/5972
dc.description.abstract Quantitative optical spectroscopy has the potential to provide an effective low cost, and portable solution for cervical pre-cancer screening in resource-limited communities. However, clinical studies to validate the use of this technology in resource-limited settings require low power consumption and good quality control that is minimally influenced by the operator or variable environmental conditions in the field. The goal of this study was to evaluate the effects of two sources of potential error: calibration and pressure on the extraction of absorption and scattering properties of normal cervical tissues in a resource-limited setting in Leogane, Haiti. Our results show that self-calibrated measurements improved scattering measurements through real-time correction of system drift, in addition to minimizing the time required for post-calibration. Variations in pressure (tested without the potential confounding effects of calibration error) caused local changes in vasculature and scatterer density that significantly impacted the tissue absorption and scattering properties Future spectroscopic systems intended for clinical use, particularly where operator training is not viable and environmental conditions unpredictable, should incorporate a real-time self-calibration channel and collect diffuse reflectance spectra at a consistent pressure to maximize data integrity.
dc.format.extent 17908 - 17924
dc.language ENG
dc.relation.ispartof Opt Express
dc.subject Acetic Acid
dc.subject Adult
dc.subject Calibration
dc.subject Early Detection of Cancer
dc.subject Female
dc.subject Haiti
dc.subject Humans
dc.subject Middle Aged
dc.subject Monte Carlo Method
dc.subject Optical Devices
dc.subject Phantoms, Imaging
dc.subject Pressure
dc.subject Sensitivity and Specificity
dc.subject Spectrum Analysis
dc.subject Uterine Cervical Neoplasms
dc.subject Vaginal Smears
dc.title Towards a field-compatible optical spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure.
dc.type Journal Article
duke.description.endpage 17924 en_US
duke.description.issue 19 en_US
duke.description.startpage 17908 en_US
duke.description.volume 19 en_US
dc.relation.journal Optics Express en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/21935155
pubs.issue 19
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/Initiatives
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/Initiatives/Duke Science & Society
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Global Health Institute
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Pharmacology & Cancer Biology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.publication-status Published
pubs.volume 19
dc.identifier.eissn 1094-4087

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