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dc.contributor.advisor Aballay, Alejandro en_US
dc.contributor.author Haskins, KA
dc.contributor.author Russell, JF
dc.contributor.author Gaddis, N
dc.contributor.author Dressman, HK
dc.contributor.author Aballay, A
dc.coverage.spatial United States
dc.date.accessioned 2008-08-15T11:56:55Z
dc.date.issued 2008-07
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/18606143
dc.identifier S1534-5807(08)00206-2
dc.identifier.citation Dev Cell, 2008, 15 (1), pp. 87 - 97
dc.identifier.uri http://hdl.handle.net/10161/685
dc.description Dissertation en_US
dc.description.abstract The endoplasmic reticulum stress response, also known as the unfolded protein response (UPR), has been implicated in the normal physiology of immune defense and in several disorders, including diabetes, cancer, and neurodegenerative disease. Here, we show that the apoptotic receptor CED-1 and a network of PQN/ABU proteins involved in a noncanonical UPR response are required for proper defense to pathogen infection in Caenorhabditis elegans. A full-genome microarray analysis indicates that CED-1 functions to activate the expression of pqn/abu genes. We also show that ced-1 and pqn/abu genes are required for the survival of C. elegans exposed to live Salmonella enterica, and that overexpression of pqn/abu genes confers protection against pathogen-mediated killing. The results indicate that unfolded protein response genes, regulated in a CED-1-dependent manner, are involved in the C. elegans immune response to live bacteria.
dc.format.extent 87 - 97
dc.format.mimetype application/pdf
dc.language eng
dc.language.iso en_US
dc.relation.ispartof Dev Cell
dc.relation.isversionof 10.1016/j.devcel.2008.05.006
dc.subject Animals
dc.subject Apoptosis
dc.subject Caenorhabditis elegans
dc.subject Caenorhabditis elegans Proteins
dc.subject Escherichia coli
dc.subject Genes
dc.subject Germ Cells
dc.subject Green Fluorescent Proteins
dc.subject Immunity, Innate
dc.subject Membrane Proteins
dc.subject Mutation
dc.subject Protein Folding
dc.subject RNA Interference
dc.subject Salmonella enterica
dc.subject Survival
dc.title Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.
dc.type Journal Article
dc.department Genetics and Genomics en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/18606143
pubs.issue 1
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Molecular Genetics and Microbiology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.publication-status Published
pubs.volume 15
dc.identifier.eissn 1878-1551

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