Show simple item record

dc.contributor.advisor Izatt, Joseph A en_US
dc.contributor.author Davis, Anjul M. en_US
dc.date.accessioned 2008-08-15T11:56:57Z
dc.date.available 2008-08-15T11:56:57Z
dc.date.issued 2008-06-05 en_US
dc.identifier.uri http://hdl.handle.net/10161/702
dc.description Dissertation en_US
dc.description.abstract <p>Developmental biology is a field in which explorations are made to answer how an organism transforms from a single cell to a complex system made up of trillions of highly organized and highly specified cells. This field, however, is not just for discovery, it is crucial for unlocking factors that lead to diseases, defects, or malformations. The one key ingredient that contributes to the success of studies in developmental biology is the technology that is available for use. Optical coherence tomography (OCT) is one such technology. OCT fills a niche between the high resolution of confocal microscopy and deep imaging penetration of ultrasound. Developmental studies of the chicken embryo heart are of great interest. Studies in mature hearts, zebrafish animal models, and to a more limited degree chicken embryos, indicate a relationship between blood flow and development. It is believed that at the earliest stages, when the heart is still a tube, the purpose of blood flow is not for convective transport of oxygen, nutrients and waster, bur rather to induce shear-related gene expressions to induce further development. Yet, to this date, the simple question of "what makes blood flow?" has not been answered. This is mainly due limited availability to adequate imaging and blood flow measurement tools. Earlier work has demonstrated the potential of OCT for use in studying chicken embryo heart development, however quantitative measurement techniques still needed to be developed. In this dissertation I present technological developments I have made towards building an OCT system to study chick embryo heart development. I will describe: 1) a swept-source OCT with extended imaging depth; 2) a spectral domain OCT system for non-invasive small animal imaging; 3) Doppler flow imaging and techniques for quantitative blood flow measurement in living chicken embryos; and 4) application of the OCT system that was developed in the Specific Aims 2-5 to test hypotheses generated by a finite element model which treats the embryonic chick heart tube as a modified peristaltic pump.</p> en_US
dc.format.extent 5667252 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.subject Engineering, Biomedical en_US
dc.subject Physics, Optics en_US
dc.subject biomedical optics en_US
dc.subject optical coherence tomography en_US
dc.subject small animal imaging en_US
dc.subject chicken embryo en_US
dc.subject Doppler en_US
dc.subject developmental biology en_US
dc.title Development of Fourier Domain Optical Coherence Tomography for Applications in Developmental Biology en_US
dc.type Dissertation en_US
dc.department Biomedical Engineering en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record