Wong, Zhee SBorrelli, Sarah L SokolCoyne, Carolyn CBoyle, Jon P2021-04-162021-04-162020-05-110020-75191879-0135https://hdl.handle.net/10161/22576Toxoplasma gondii is remarkably unique in its ability to successfully infect vertebrate hosts from multiple phyla and can successfully infect most cells within these organisms. The infection outcome in each of these species is determined by the complex interaction between parasite and host genotype. As techniques to quantify global changes in cell function become more readily available and precise, new data are coming to light about how (i) different host cell types respond to parasitic infection and (ii) different parasite species impact the host. Here we focus on recent studies comparing the response to intracellular parasitism by different cell types and insights into understanding host-parasite interactions from comparative studies on T. gondii and its close extant relatives.Cell LineAnimalsMammalsHumansApicomplexaNeosporaToxoplasmaCoccidiosisToxoplasmosisProtein-Serine-Threonine KinasesChemokinesVirulenceImmunityGene ExpressionTumor Suppressor Protein p53Host-Parasite InteractionsInterferon-gammaBiological EvolutionHost SpecificityTranscriptomeTHP-1 CellsJournal article2021-04-16