Kim, Han JoAlluri, R KiranLafage, RenaudElysee, JonathanSmith, Justin SMundis, Gregory MShaffrey, Christopher IAmes, Christopher PBurton, Douglas CKlineberg, Eric OBess, ShaySchwab, FrankGupta, MunishLafage, VirginieInternational Spine Study Group (ISSG)2023-06-152023-06-152022-080362-24361528-1159https://hdl.handle.net/10161/28002<h4>Study design</h4>Retrospective study of a multicenter Adult Spinal Deformity (ASD) Database.<h4>Objective</h4>To investigate the change in Pelvic tilt (PT) imparted by regional changes in lumbar lordosis at 2-year minimum follow up.<h4>Summary of background data</h4>The distribution of lumbar lordosis between L1-4 and L4-S1 is known to vary based on pelvic incidence (PI). However, the extent to which regional changes effect PT is not clearly elucidated. This information can be useful for ASD surgical planning.<h4>Methods</h4>Operative patients from a multicenter ASD database were included with Lowest Instrumented Vertebrae (LIV) S1/Ilium, >5 levels of fusion, Proximal Junction Kyphosis (PJK) angle < 20, and >5 degrees of change in lumbar lordosis from L4-S1 and L1-4. Radiographic analysis was performed evaluating Thoracic Kyphosis (TK), T10-L2 kyphosis (TL), L1-S1 lordosis (LL), L4-S1 lordosis, L1-4 lordosis, sagittal vertical axis (SVA) and PI-LL from preoperative to postoperative, and change at 2-years follow-up. Stepwise regression analysis was performed in order to determine the relationship between PT and the above radiographic parameters. Health-related quality of life (HRQOL) outcomes were also compared between preoperative and postoperative timepoints at 2 years.<h4>Results</h4>103 patients met inclusion for the study. There was improvement in all the radiographic parameters and HRQOLs at 2 years follow-up (p < 0.01). Stepwise regression model showed an inverse relationship between PT and LL change (r = 0.71, p < 0.01). Regionally, an increase in 10 degrees from L4-S1 correlated with a 2.4 degree decrease in PT (p < 0.01), while an increase in 10 degrees from L1-4 resulted in a 1.6 degree decrease in PT (p < 0.01).<h4>Conclusion</h4>In the surgical planning for ASD, our data demonstrated significant correlational difference between corrections in the upper (L1-4) and lower (L4-S1) lumbar spine and PT changes. These calculations can be useful in planning sagittal plane corrections for ASD.International Spine Study Group (ISSG)Lumbar VertebraeThoracic VertebraeHumansKyphosisLordosisSpinal FusionRetrospective StudiesFollow-Up StudiesQuality of LifeAdultJournal article2023-06-15