Patel, RobinPolage, Christopher RDien Bard, JenniferMay, LarissaLee, Francesca MFabre, ValeriaHayden, Mary KDoernberg, Sarah DBHaake, David ATrautner, Barbara WGrigoryan, LarissaTsalik, Ephraim LHanson, Kimberly E2022-03-012022-03-012021-08-311058-48381537-6591https://hdl.handle.net/10161/24503Urinary tract infections (UTIs) are among the most common bacterial infections in the United States and are a major driver of antibiotic use - both appropriate and inappropriate - across healthcare settings. UTI treatment has become complex due to antibacterial resistance; one quarter of urinary tract isolates of Escherichia coli in the United States in 2017 were resistant to fluoroquinolones and one third to trimethoprimsulfamethoxazole (1), agents with historically predictable activity against E. coli. As a result, more broad-spectrum antibiotics are being used to treat UTIs, contributing to selection of further antibiotic resistance.urinary tract infectionUTIlaboratory diagnosisdiagnosticsJournal article2022-03-01