Leung, WilsonShaffer, Christopher DReed, Laura KSmith, Sheryl TBarshop, WilliamDirkes, WilliamDothager, MatthewLee, PaulWong, JeannetteXiong, DavidYuan, HanBedard, James EJMachone, Joshua FPatterson, Seantay DPrice, Amber LTurner, Bryce ARobic, SrebrenkaLuippold, Erin KMcCartha, Shannon RWalji, Tezin AWalker, Chelsea ASaville, KennethAbrams, Marita KArmstrong, Andrew RArmstrong, WilliamBailey, Robert JBarberi, Chelsea RBeck, Lauren RBlaker, Amanda LBlunden, Christopher EBrand, Jordan PBrock, Ethan JBrooks, Dana WBrown, MarieButzler, Sarah CClark, Eric MClark, Nicole BCollins, Ashley ACotteleer, Rebecca JCullimore, Peterson RDawson, Seth GDocking, Carter TDorsett, Sasha LDougherty, Grace ADowney, Kaitlyn ADrake, Andrew PEarl, Erica KFloyd, Trevor GForsyth, Joshua DFoust, Jonathan DFranchi, Spencer LGeary, James FHanson, Cynthia KHarding, Taylor SHarris, Cameron BHeckman, Jonathan MHolderness, Heather LHowey, Nicole AJacobs, Dontae AJewell, Elizabeth SKaisler, MariaKaraska, Elizabeth AKehoe, James LKoaches, Hannah CKoehler, JessicaKoenig, DanaKujawski, Alexander JKus, Jordan ELammers, Jennifer ALeads, Rachel RLeatherman, Emily CLippert, Rachel NMessenger, Gregory SMorrow, Adam TNewcomb, VictoriaPlasman, Haley JPotocny, Stephanie JPowers, Michelle KReem, Rachel MRennhack, Jonathan PReynolds, Katherine RReynolds, Lyndsey ARhee, Dong KRivard, Allyson BRonk, Adam JRooney, Meghan BRubin, Lainey SSalbert, Luke RSaluja, Rasleen KSchauder, TaylorSchneiter, Allison RSchulz, Robert WSmith, Karl ESpencer, SarahSwanson, Bryant RTache, Melissa ATewilliager, Ashley ATilot, Amanda KVanEck, EveVillerot, Matthew MVylonis, Megan BWatson, David TWurzler, Juliana AWysocki, Lauren MYalamanchili, MonicaZaborowicz, Matthew AEmerson, Julia AOrtiz, CarlosDeuschle, Frederic JDiLorenzo, Lauren AGoeller, Katie LMacchi, Christopher RMuller, Sarah EPasierb, Brittany DSable, Joseph ETucci, Jessica MTynon, MarykathrynDunbar, David ABeken, Levent HConturso, Alaina CDanner, Benjamin LDeMichele, Gabriella AGonzales, Justin AHammond, Maureen SKelley, Colleen VKelly, Elisabeth AKulich, DanielleMageeney, Catherine MMcCabe, Nikie LNewman, Alyssa MSpaeder, Lindsay ATumminello, Richard ARevie, DennisBenson, Jonathon MCristostomo, Michael CDaSilva, Paolo AHarker, Katherine SJarrell, Jenifer NJimenez, Luis AKatz, Brandon MKennedy, William RKolibas, Kimberly SLeBlanc, Mark TNguyen, Trung TNicolas, Daniel SPatao, Melissa DPatao, Shane MRupley, Bryan JSessions, Bridget JWeaver, Jennifer AGoodman, Anya LAlvendia, Erica LBaldassari, Shana MBrown, Ashley SChase, Ian OChen, MaidaChiang, ScottCromwell, Avery BCuster, Ashley FDiTommaso, Tia MEl-Adaimi, JadGoscinski, Nora CGrove, Ryan AGutierrez, NestorHarnoto, Raechel SHedeen, HeatherHong, Emily LHopkins, Barbara LHuerta, Vilma FKhoshabian, ColinLaForge, Kristin MLee, Cassidy TLewis, Benjamin MLydon, Anniken MManiaci, Brian JMitchell, Ryan DMorlock, Elaine VMorris, William MNaik, PriyankaOlson, Nicole COsterloh, Jeannette MPerez, Marcos APresley, Jonathan DRandazzo, Matt JRegan, Melanie KRossi, Franca GSmith, Melanie ASoliterman, Eugenia ASparks, Ciani JTran, Danny LWan, TiffanyWelker, Anne AWong, Jeremy NSreenivasan, AparnaYoungblom, JimAdams, AndrewAlldredge, JustinBryant, AshleyCarranza, DavidCifelli, AlyssaCoulson, KevinDebow, CaliseDelacruz, NoelleEmerson, CharleneFarrar, CassandraForet, DonGaribay, EdgarGooch, JohnHeslop, MichelleKaur, SukhjitKhan, AmbreenKim, VanLamb, TravisLindbeck, PeterLucas, GabiMacias, ElizabethMartiniuc, DanielaMayorga, LissettMedina, JosephMembreno, NelsonMessiah, ShadyNeufeld, LaceyNguyen, San FranciscoNichols, ZacharyOdisho, GeorgePeterson, DaymonRodela, LauraRodriguez, PriscillaRodriguez, VanessaRuiz, JorgeSherrill, WillSilva, ValeriaSparks, JeriStatton, GeetaTownsend, AshleyValdez, IsabelWaters, MaryWestphal, KyleWinkler, StaceyZumkehr, JoanneeDeJong, Randall JHoogewerf, Arlene JAckerman, Cheri MArmistead, Isaac OBaatenburg, LaraBorr, Matthew JBrouwer, Lindsay KBurkhart, Brandon JBushhouse, Kelsey TCesko, LejlaChoi, Tiffany YYCohen, HeatherDamsteegt, Amanda MDarusz, Jess MDauphin, Cory MDavis, Yelena PDiekema, Emily JDrewry, MelissaEisen, Michelle EMFaber, Hayley MFaber, Katherine JFeenstra, ElizabethFelzer-Kim, Isabella THammond, Brandy LHendriksma, JesseHerrold, Milton RHilbrands, Julia AHowell, Emily JJelgerhuis, Sarah AJelsema, Timothy RJohnson, Benjamin KJones, Kelly KKim, AnnaKooienga, Ross DMenyes, Erika ENollet, Eric APlescher, Brittany ERios, LindsayRose, Jenny LSchepers, Allison JScott, GeoffSmith, Joshua RSterling, Allison MTenney, Jenna CUitvlugt, ChrisVanDyken, Rachel EVanderVennen, MarielleVue, SamanthaKokan, Nighat PAgbley, KwabeaBoham, Sampson KBroomfield, DanielChapman, KaylaDobbe, AliDobbe, IanHarrington, WilliamIbrahem, MarwanKennedy, AndreKoplinsky, Chad AKubricky, CassandraLadzekpo, DaniellePattison, ClaireRamirez, Roman EWande, LuciaWoehlke, SarahWawersik, MatthewKiernan, ElizabethThompson, Jeffrey SBanker, RoxanneBartling, Justina RBhatiya, Chinmoy IBoudoures, Anna LChristiansen, LenaFosselman, Daniel SFrench, Kristin MGill, Ishwar SHavill, Jessen TJohnson, Jaelyn LKeny, Lauren JKerber, John MKlett, Bethany MKufel, Christina NMay, Francis JMecoli, Jonathan PMerry, Callie RMeyer, Lauren RMiller, Emily GMullen, Gregory JPalozola, Katherine CPfeil, Jacob JThomas, Jessica GVerbofsky, Evan MSpana, Eric PAgarwalla, AnantChapman, JuliaChlebina, BenChong, InsunFalk, INFitzgibbons, John DFriedman, HarrisonIghile, OsagieKim, Andrew JKnouse, Kristin AKung, FaithMammo, DannyNg, Chun LeungNikam, Vinayak SNorton, DianaPham, PhilipPolk, Jessica WPrasad, ShreyaRankin, HelenRatliff, Camille DScala, VictoriaSchwartz, Nicholas UShuen, Jessica AXu, AmyXu, Thomas QZhang, YiRosenwald, Anne GBurg, Martin GAdams, Stephanie JBaker, MorganBotsford, BobbiBrinkley, BrianaBrown, CarterEmiah, ShadieEnoch, EricaGier, ChadGreenwell, AlysonHoogenboom, LindsayMatthews, Jordan EMcDonald, MitchellMercer, AmandaMonsma, NicholausOstby, KristineRamic, AlenShallman, DevonSimon, MatthewSpencer, EricTomkins, TrishaWendland, PeteWylie, AnnaWolyniak, Michael JRobertson, Gregory MSmith, Samuel IDiAngelo, Justin RSassu, Eric DBhalla, Satish CSharif, Karim AChoeying, TenzinMacias, Jason SSanusi, FareedTorchon, KarvynBednarski, April EAlvarez, Consuelo JDavis, Kristen CDunham, Carrie AGrantham, Alaina JHare, Amber NSchottler, JenniferScott, Zackary WKuleck, Gary AYu, Nicole SKaehler, Marian MJipp, JacobOvervoorde, Paul JShoop, ElizabethCyrankowski, OliviaHoover, BetsyKusner, MattLin, DevryMartinov, TijanaMisch, JonathanSalzman, GarrettSchiedermayer, HollySnavely, MichaelZarrasola, StephanieParrish, SusanBaker, AtleeBeckett, AlissaBelella, CarissaBryant, JulieConrad, TurnerFearnow, AdamGomez, CarolinaHerbstsomer, Robert AHirsch, SarahJohnson, ChristenJones, MelissaKabaso, RitaLemmon, EricVieira, Carolina Marques Dos SantosMcFarland, DarrylMcLaughlin, ChristopherMorgan, AbbieMusokotwane, SepoNeutzling, WilliamNietmann, JanaPaluskievicz, ChristinaPenn, JessicaPeoples, EmilyPozmanter, CaitlinReed, EmilyRigby, NicholeSchmidt, LasseShelton, MicahShuford, RebeccaTirasawasdichai, TiaraUndem, BlairUrick, DamianVondy, KaylaYarrington, BryanEckdahl, Todd TPoet, Jeffrey LAllen, Alica BAnderson, John EBarnett, Jason MBaumgardner, Jordan SBrown, Adam DCarney, Jordan EChavez, Ramiro AChristgen, Shelbi LChristie, Jordan SClary, Andrea NConn, Michel ACooper, Kristen MCrowley, Matt JCrowley, Samuel TDoty, Jennifer SDow, Brian AEdwards, Curtis RElder, Darcie DFanning, John PJanssen, Bridget MLambright, Anthony KLane, Curtiss ELimle, Austin BMazur, TammyMcCracken, Marly RMcDonough, Alexa MMelton, Amy DMinnick, Phillip JMusick, Adam ENewhart, William HNoynaert, Joseph WOgden, Bradley JSandusky, Michael WSchmuecker, Samantha MShipman, Anna LSmith, Anna LThomsen, Kristen MUnzicker, Matthew RVernon, William BWinn, Wesley WWoyski, Dustin SZhu, XiaoDu, ChunguangAment, CaitlinAso, SohamBisogno, Laura SimoneCaronna, JasonFefelova, NadezhdaLopez, LeninMalkowitz, LorraineMarra, JonathanMenillo, DaniellaObiorah, IfeanyiOnsarigo, Eric NyabetaPrimus, ShekerahSoos, MahdiTare, ArchanaZidan, AmeerJones, Christopher JAronhalt, ToddBellush, James MBurke, ChristaDeFazio, SteveDoes, Benjamin RJohnson, Todd DKeysock, NicholasKnudsen, Nelson HMessler, JamesMyirski, KevinRekai, Jade LeaRempe, Ryan MichaelSalgado, Michael SStagaard, EricaStarcher, Justin RWaggoner, Andrew WYemelyanova, Anastasia KHark, Amy TBertolet, AnneKuschner, Cyrus EParry, KesleyQuach, MichaelShantzer, LindseyShaw, Mary ESmith, Mary AGlenn, OmolaraMason, PortiaWilliams, CharlotteKey, S Catherine SilverHenry, Tyneshia CPJohnson, Ashlee GWhite, Jackie XHaberman, AdamAsinof, SamDrumm, KellyFreeburg, TripSafa, NadiaSchultz, DarrinShevin, YakovSvoronos, PetrosVuong, TamWellinghoff, JulesHoopes, Laura LMChau, Kim MWard, AlyssaRegisford, E Gloria CAugustine, LaJeraldDavis-Reyes, BrionnaEchendu, VivienneHales, JasmineIbarra, SharonJohnson, LauriaunOvu, StevenBraverman, John MBahr, Thomas JCaesar, Nicole MCampana, ChristopherCassidy, Daniel WCognetti, Peter AEnglish, Johnathan DFadus, Matthew CFick, Cameron NFreda, Philip JHennessy, Bryan MHockenberger, KelseyJones, Jennifer KKing, Jessica EKnob, Christopher RKraftmann, Karen JLi, LinghuiLupey, Lena NMinniti, Carl JMinton, Thomas FMoran, Joseph VMudumbi, KrishnaNordman, Elizabeth CPuetz, William JRobinson, Lauren MRose, Thomas JSweeney, Edward PTimko, Ashley SPaetkau, Don WEisler, Heather LAldrup, Megan EBodenberg, Jessica MCole, Mara GDeranek, Kelly MDeShetler, MeganDowd, Rose MEckardt, Alexandra KEhret, Sharon CFese, JessicaGarrett, Amanda DKammrath, AnnaKappes, Michelle LLight, Morgan RMeier, Anne CO'Rouke, AllisonPerella, MalloryRamsey, KimberleyRamthun, Jennifer RReilly, Mary TRobinett, DeirdreRossi, Nadine LSchueler, Mary GraceShoemaker, EmmaStarkey, Kristin MVetor, AshleyVrable, AbbyChandrasekaran, VidyaBeck, ChristopherHatfield, Kristen RHerrick, Douglas AKhoury, Christopher BLea, CharlotteLouie, Christopher ALowell, Shannon MReynolds, Thomas JSchibler, JeanineScoma, Alexandra HSmith-Gee, Maxwell TTuberty, SarahSmith, Christopher DLopilato, Jane EHauke, JeanetteRoecklein-Canfield, Jennifer ACorrielus, MaureenGilman, HannahIntriago, StephanieMaffa, AmandaRauf, Sabya AThistle, KatrinaTrieu, MelissaWinters, JeniferYang, BibHauser, Charles RAbusheikh, TariqAshrawi, YaraBenitez, PedroBoudreaux, Lauren RBourland, MeganChavez, MirandaCruz, SamanthaElliott, GiNellFarek, Jesse RFlohr, SarahFlores, Amanda HFriedrichs, ChelseyFusco, ZachGoodwin, ZaneHelmreich, EricKiley, JohnKnepper, John MarkLangner, ChristineMartinez, MeganMendoza, CarlosNaik, MonalOchoa, AndreaRagland, NicolasRaimey, EnglandRathore, SunilReza, EvangelinaSadovsky, GriffinSeydoux, Marie-Isabelle BSmith, Jonathan EUnruh, Anna KVelasquez, VicenteWolski, Matthew WGosser, YuyingGovind, ShubhaClarke-Medley, NicoleGuadron, LeslieLau, DawnLu, AlvinMazzeo, CherylMeghdari, MariamNg, SimonPamnani, BradPlante, OliviaShum, Yuki Kwan WaSong, RoyJohnson, Diana EAbdelnabi, MaiArchambault, AlexiChamma, NormaGaur, ShaillyHammett, DeborahKandahari, AdreseKhayrullina, GuzalKumar, SonaliLawrence, SamanthaMadden, NigelMandelbaum, MaxMilnthorp, HeatherMohini, ShivPatel, RoshniPeacock, Sarah JPerling, EmilyQuintana, AmberRahimi, MichaelRamirez, KristenSinghal, RishiWeeks, CorinneWong, TiffanyGillis, Aubree TMoore, Zachary DSavell, Christopher DWatson, ReeceMel, Stephanie FAnilkumar, Arjun ABilinski, PaulCastillo, RostislavClosser, MichaelCruz, Nathalia MDai, TiffanyGarbagnati, Giancarlo FHorton, Lanor SKim, DongyeonLau, Joyce HLiu, James ZMach, Sandy DPhan, Thu ARen, YiStapleton, Kenneth EStrelitz, Jean MSunjed, RayStamm, JoyceAnderson, Morgan CBonifield, Bethany GraceCoomes, DanielDillman, AdamDurchholz, Elaine JFafara-Thompson, Antoinette EGross, Meleah JGygi, Amber MJackson, Lesley EJohnson, AmyKocsisova, ZuzanaManghelli, Joshua LMcNeil, KylieMurillo, MichaelNaylor, Kierstin LNeely, JessicaOgawa, Emmy ERich, AshleyRogers, AnnaSpencer, J DevinStemler, Kristina MThrom, Allison AVan Camp, MattWeihbrecht, KatieWiles, T AaronWilliams, Mallory AWilliams, MatthewZoll, KyleBailey, CherylZhou, LemingBalthaser, Darla MBashiri, AzitaBower, Mindy EFlorian, Kayla AGhavam, NazaninGreiner-Sosanko, Elizabeth SKarim, HelmetMullen, Victor WPelchen, Carly EYenerall, Paul MZhang, JiayuRubin, Michael RArias-Mejias, Suzette MBermudez-Capo, Armando GBernal-Vega, Gabriela VColon-Vazquez, MarielaFlores-Vazquez, ArelysGines-Rosario, MarielaLlavona-Cartagena, Ivan GMartinez-Rodriguez, Javier OOrtiz-Fuentes, LionelPerez-Colomba, Eliezer OPerez-Otero, JosephRivera, ElisandraRodriguez-Giron, Luke JSantiago-Sanabria, Arnaldo JSenquiz-Gonzalez, Andrea MdelValle, Frank R SotoVargas-Franco, DorianmarieVelázquez-Soto, Karla IZambrana-Burgos, Joan DMartinez-Cruzado, Juan CarlosAsencio-Zayas, LillyannBabilonia-Figueroa, KevinBeauchamp-Pérez, Francis DBelén-Rodríguez, JulianaBracero-Quiñones, LuciannBurgos-Bula, Andrea PCollado-Méndez, Xavier AColón-Cruz, Luis RCorrea-Muller, Ana ICrooke-Rosado, Jonathan LCruz-García, José MDefendini-Ávila, MariannaDelgado-Peraza, Francheska MFeliciano-Cancela, Alex JGónzalez-Pérez, Valerie MGuiblet, WilfriedHeredia-Negrón, AldoHernández-Muñiz, JenniferIrizarry-González, Lourdes NLaboy-Corales, Ángel LLlaurador-Caraballo, Gabriela AMarín-Maldonado, FrancesMarrero-Llerena, UlisesMartell-Martínez, Héctor AMartínez-Traverso, Idaliz MMedina-Ortega, Kiara NMéndez-Castellanos, Sonya GMenéndez-Serrano, Krizia CMorales-Caraballo, Carol IOrtiz-DeChoudens, SaryleineOrtiz-Ortiz, PatriciaPagán-Torres, HendrickPérez-Afanador, DianaQuintana-Torres, Enid MRamírez-Aponte, Edwin GRiascos-Cuero, CarolinaRivera-Llovet, Michelle SRivera-Pagán, Ingrid TRivera-Vicéns, Ramón ERobles-Juarbe, FabiolaRodríguez-Bonilla, LorraineRodríguez-Echevarría, Brian ORodríguez-García, Priscila MRodríguez-Laboy, Abneris ERodríguez-Santiago, SusanaRojas-Vargas, Michael LRubio-Marrero, Eva NSantiago-Colón, AlbelizSantiago-Ortiz, Jorge LSantos-Ramos, Carlos ESerrano-González, JoselineTamayo-Figueroa, Alina MTascón-Peñaranda, Edna PTorres-Castillo, José LValentín-Feliciano, Nelson AValentín-Feliciano, Yashira MVargas-Barreto, Nadyan MVélez-Vázquez, MiguelVilanova-Vélez, Luis RZambrana-Echevarría, CristinaMacKinnon, ChristyChung, Hui-MinKay, ChrisPinto, AnthonyKopp, Olga RBurkhardt, JoshuaHarward, ChrisAllen, RobertBhat, PavanChang, Jimmy Hsiang-ChunChen, YorkChesley, ChristopherCohn, DaraDuPuis, DavidFasano, MichaelFazzio, NicholasGavinski, KatherineGebreyesus, HeranGiarla, ThomasGostelow, MarcusGreenstein, RachelGunasinghe, HashiniHanson, CaseyHay, AmandaHe, Tao JianHoma, KatieHowe, RuthHowenstein, JeffHuang, HenryKhatri, AadityaKim, Young LuKnowles, OliviaKong, SarahKrock, RebeccaKroll, MattKuhn, JuliaKwong, MatthewLee, BrandonLee, RyanLevine, KevinLi, YeddaLiu, BoLiu, LucyLiu, MaxLousararian, AdamMa, JimmyMallya, AllysonManchee, CharlieMarcus, JosephMcDaniel, StephenMiller, Michelle LMolleston, Jerome MDiez, Cristina MonteroNg, PatrickNgai, NatalieNguyen, HienNylander, AndrewPollack, JasonRastogi, SuchitaReddy, HimabinduRegenold, NathanielSarezky, JonSchultz, MichaelShim, JienSkorupa, TaraSmith, KennethSpencer, Sarah JSrikanth, PriyaStancu, GabrielStein, Andrew PStrother, MarshallSudmeier, LisaSun, MengyangSundaram, VarunTazudeen, NoorTseng, AlanTzeng, AlbertVenkat, RohitVenkataram, SandeepWaldman, LeahWang, TracyYang, HaoYu, Jack YZheng, YinPreuss, Mary LGarcia, AngelicaJuergens, MattMorris, Robert WNagengast, Alexis AAzarewicz, JulieCarr, Thomas JChichearo, NicoleColgan, MikeDonegan, MeganGardner, BobKolba, NikKrumm, Janice LLytle, StaceyMacMillian, LaurellMiller, MaryMontgomery, AndrewMoretti, AlyshaOffenbacker, BrittneyPolen, MikeToth, JohnWoytanowski, JohnKadlec, LisaCrawford, JustinSpratt, Mary LAdams, Ashley LBarnard, Brianna KCheramie, Martin NEime, Anne MGolden, Kathryn LHawkins, Allyson PHill, Jessica EKampmeier, Jessica AKern, Cody DMagnuson, Emily EMiller, Ashley RMorrow, Cody MPeairs, Julia CPickett, Gentry LPopelka, Sarah AScott, Alexis JTeepe, Emily JTerMeer, Katie AWatchinski, Carmen AWatson, Lucas AWeber, Rachel EWoodard, Kate ABarnard, Daron CAppiah, IsaacGiddens, Michelle MMcNeil, Gerard PAdebayo, AdeolaBagaeva, KateChinwong, JustinaDol, ChrystelGeorge, EuniceHaltaufderhyde, KirkHaye, JoannaKaur, ManpreetSemon, MaxSerjanov, DmitriToorie, AnikaWilson, ChristopherRiddle, Nicole CBuhler, JeremyMardis, Elaine RElgin, Sarah CR2021-09-032021-09-032015-03-042160-18362160-1836https://hdl.handle.net/10161/23707The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25-50%) than euchromatic reference regions (3-11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11-27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4-3.6 vs. 8.4-8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu.HeterochromatinAnimalsDrosophilaDrosophila melanogasterDrosophila ProteinsDNA Transposable ElementsCodonComputational BiologyGenomicsEvolution, MolecularSpecies SpecificityGene RearrangementRepetitive Sequences, Nucleic AcidGenomeIntronsExonsSelection, GeneticMolecular Sequence AnnotationPolytene ChromosomesJournal article2021-09-03