Profit, JochenAdair, Kathryn CCui, XinMitchell, BrianaBrandon, DebraTawfik, Daniel SRigdon, JosephGould, Jeffrey BLee, Henry CTimpson, Wendy LMcCaffrey, Martin JDavis, Alexis SPammi, MohanMatthews, MelissaStark, Ann RPapile, Lu-AnnThomas, EricCotten, MichaelKhan, AmirSexton, J Bryan2021-09-012021-09-012021-08-090743-83461476-5543https://hdl.handle.net/10161/23669<h4>Objective</h4>Test web-based implementation for the science of enhancing resilience (WISER) intervention efficacy in reducing healthcare worker (HCW) burnout.<h4>Design</h4>RCT using two cohorts of HCWs of four NICUs each, to improve HCW well-being (primary outcome: burnout). Cohort 1 received WISER while Cohort 2 acted as a waitlist control.<h4>Results</h4>Cohorts were similar, mostly female (83%) and nurses (62%). In Cohorts 1 and 2 respectively, 182 and 299 initiated WISER, 100 and 176 completed 1-month follow-up, and 78 and 146 completed 6-month follow-up. Relative to control, WISER decreased burnout (-5.27 (95% CI: -10.44, -0.10), p = 0.046). Combined adjusted cohort results at 1-month showed that the percentage of HCWs reporting concerning outcomes was significantly decreased for burnout (-6.3% (95%CI: -11.6%, -1.0%); p = 0.008), and secondary outcomes depression (-5.2% (95%CI: -10.8, -0.4); p = 0.022) and work-life integration (-11.8% (95%CI: -17.9, -6.1); p < 0.001). Improvements endured at 6 months.<h4>Conclusion</h4>WISER appears to durably improve HCW well-being.<h4>Clinical trials number</h4>NCT02603133; https://clinicaltrials.gov/ct2/show/NCT02603133.Journal article2021-09-01