Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues

Rajic, ZrinkaTovmasyan, Artakde Santana, Otávio LPeixoto, Isabelle NSpasojevic, Ivando Monte, Silmar AVentura, ElizeteRebouças, Júlio SBatinic-Haberle, Ines2020-07-152020-07-152017-04-010162-01341873-3344https://hdl.handle.net/10161/21193Science & TechnologyLife Sciences & BiomedicinePhysical SciencesBiochemistry & Molecular BiologyChemistry, Inorganic & NuclearChemistrySOD mimicsAlkoxyalkyl tosylatesMn N-alkoxyalkylpyridylporphyrinsMnTnBuOE-2-PyP5+ (BMX-001)MnTTEG-2-PyP5+FP-15Mechanism of pyridyl nitrogen quatemizationPEROXYNITRITE DECOMPOSITION CATALYSTSOD MIMICSOXIDATIVE-STRESSMANGANESE-PORPHYRINBASIS-SETSIN-VIVOBIOAVAILABILITYMNTE-2-PYP5+CHEMISTRYENERGIESChallenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analoguesJournal article2020-07-15