Wang, QiuNguyen, Andrew2024-03-072023https://hdl.handle.net/10161/30237<p>Heterocycles represent an important class of motifs found in many bioactive molecules, pharmaceuticals, and agrochemicals. The ability to rapidly construct a diverse set of these compounds remains an important endeavor in the field of synthetic chemistry. In this thesis, an intramolecular 1,3-difunctionalization of cyclopropanes is reported using a copper-NFSI catalyzed system. Direct oxidation of the substrate by a nitrogen centered radical activates the cyclopropane which then undergoes a ring-opening cascade to produce a variety of lactones, cyclic ethers, pyrrolidines, and oximes containing γ-amino functionalization. Further product derivatization can produce various protected amines and alkyl-sulfonamides. </p>https://creativecommons.org/licenses/by-nc-nd/4.0/Organic chemistryMaster's thesis