Madut, Deng BRubach, Matthew PKalengo, NathanielCarugati, ManuelaMaze, Michael JMorrissey, Anne BMmbaga, Blandina TLwezaula, Bingileki FKilonzo, Kajiru GMaro, Venance PCrump, John A2024-01-252024-01-252020-050035-92031878-3503https://hdl.handle.net/10161/29841<h4>Background</h4>Characterization of the epidemiology of Escherichia coli bloodstream infection (BSI) in sub-Saharan Africa is lacking. We studied patients with E. coli BSI in northern Tanzania to describe host risk factors for infection and to describe the antimicrobial susceptibility of isolates.<h4>Methods</h4>Within 24 h of admission, patients presenting with a fever at two hospitals in Moshi, Tanzania, were screened and enrolled. Cases were patients with at least one blood culture yielding E. coli and controls were those without E. coli isolated from any blood culture. Logistic regression was used to identify host risk factors for E. coli BSI.<h4>Results</h4>We analyzed data from 33 cases and 1615 controls enrolled from 2007 through 2018. The median (IQR) age of cases was 47 (34-57) y and 24 (72.7%) were female. E. coli BSI was associated with (adjusted OR [aOR], 95% CI) increasing years of age (1.03, 1.01 to 1.05), female gender (2.20, 1.01 to 4.80), abdominal tenderness (2.24, 1.06 to 4.72) and urinary tract infection as a discharge diagnosis (3.71, 1.61 to 8.52). Of 31 isolates with antimicrobial susceptibility results, the prevalence of resistance was ampicillin 29 (93.6%), ceftriaxone three (9.7%), ciprofloxacin five (16.1%), gentamicin seven (22.6%) and trimethoprim-sulfamethoxazole 31 (100.0%).<h4>Conclusions</h4>In Tanzania, host risk factors for E. coli BSI were similar to those reported in high-resource settings and resistance to key antimicrobials was common.HumansEscherichia coliBacteremiaEscherichia coli InfectionsAnti-Bacterial AgentsMicrobial Sensitivity TestsProspective StudiesDrug Resistance, BacterialAdolescentAdultTanzaniaFemaleJournal article