Bergelson, ElikaIdsardi, William J2017-12-012017-12-012009-02-18https://hdl.handle.net/10161/15805Our findings provide magnetoencephalographic evidence that the mismatch-negativity response to two-note chords (dyads) is modulated by a combination of abstract cognitive differences and lower-level differences in the auditory signal. Participants were presented with series of simple-ratio sinusoidal dyads (perfect fourths and perfect fifths) in which the difference between the standard and deviant dyad exhibited an interval change, a shift in pitch space, or both. In addition, the standard-deviant pair of dyads either shared one note or both notes were changed. Only the condition that featured both abstract changes (interval change and pitch-space shift) and two novel notes showed a significantly larger magnetoencephalographic mismatch-negativity response than the other conditions in the right hemisphere. Implications for music and language processing are discussed.Acoustic StimulationAdultAuditory CortexBrain MappingCognitionEvoked PotentialsFemaleFunctional LateralityHumansMagnetoencephalographyMaleMiddle AgedMusicNeuronal PlasticityNeuropsychological TestsPeriodicityPitch PerceptionReaction TimeSoundSpeech PerceptionTime FactorsYoung AdultJournal article1473-558X