Rocos, BrettWhitehouse, Michael RKelly, Michael B2024-01-102024-01-102017-052044-60552044-6055https://hdl.handle.net/10161/29707To evaluate the evidence for the resuscitation of patients with hip fracture in the preoperative or perioperative phase of their treatment and its impact on mortality.<h4>Design</h4>We searched MEDLINE, EMBASE, CENTRAL and PROSPERO databases using a systematic search strategy for randomised trials and observational studies investigating the fluid resuscitation of any patient with hip fracture. No language limits were applied to the search, which was complemented by manually screening the reference lists of appropriate studies.<h4>Outcome measures</h4>Mortality at 1 week, 30 days and 1 year following surgery.<h4>Results</h4>Two hundred and ninety-eight citations were identified, and 12 full manuscripts were reviewed; no studies satisfied the inclusion criteria. The background literature showed that the mortality for these patients at 30 days is approximately 8.5% and that bone cement implantation syndrome is insufficient to explain this. The literature was explored to define the need for an interventional investigation into the preoperative resuscitation of patients with hip fracture.<h4>Conclusions</h4>Patients with hip fracture show similar physiological disturbance to major trauma patients. Nineteen per cent of patients presenting with hip fracture are hypoperfused and 50% show preoperative anaemia suggesting that under resuscitation is a common problem that has not been investigated. A properly conducted interventional trial could improve the outcome of these vulnerable patients.HumansAnemiaHip FracturesPostoperative ComplicationsResuscitationEvidence-Based MedicineAge FactorsComorbidityBiomedical ResearchEnglandJournal article