Patel, RobinTsalik, Ephraim LEvans, ScottFowler, Vance GDoernberg, Sarah BAntibacterial Resistance Leadership Group2023-04-012023-04-012023-031058-48381537-6591https://hdl.handle.net/10161/26953Lack of a gold standard can present a challenge for evaluation of diagnostic test accuracy of some infectious diseases tests, particularly when the test's accuracy potentially exceeds that of its predecessors. This approach may measure agreement with an imperfect reference, rather than correctness, because the right answer is unknown. Solutions consist of multitest comparators, including those that involve a test under evaluation if multiple new tests are being evaluated together, using latent class modeling, and clinically adjudicated reference standards. Clinically adjudicated reference standards may be considered as comparator methods when no predefined test or composite of tests is sufficiently accurate; they emulate clinical practice in that multiple data pieces are clinically assessed together.Antibacterial Resistance Leadership GroupHumansCommunicable DiseasesDiagnostic Tests, RoutineSensitivity and SpecificityReference StandardsJournal article2023-04-01