Williamson, Tyler KMir, Jamshaid MSmith, Justin SLafage, VirginieLafage, RenaudLine, BretonDiebo, Bassel GDaniels, Alan HGum, Jeffrey LHamilton, D KojoScheer, Justin KEastlack, RobertDemetriades, Andreas KKebaish, Khaled MLewis, StephenLenke, Lawrence GHostin, Richard AGupta, Munish CKim, Han JoAmes, Christopher PBurton, Douglas CShaffrey, Christopher IKlineberg, Eric OBess, ShayPassias, Peter GInternational Spine Study Group2024-06-192024-06-192024-062212-134X2212-1358https://hdl.handle.net/10161/31199<h4>Background</h4>Research has focused on the increased correction from a three-column osteotomy (3CO) during adult spinal deformity (ASD) surgery. However, an in-depth analysis on the performance of a 3CO in a cohort of complex spinal deformity cases has not been described.<h4>Study design/setting</h4>This is a retrospective study on a prospectively enrolled, complex ASD database.<h4>Purpose</h4>This study aimed to determine if three-column osteotomies demonstrate superior benefit in correction of complex sagittal deformity at the cost of increased perioperative complications.<h4>Methods</h4>Surgical complex adult spinal deformity patients were included and grouped into thoracolumbar 3COs compared to those who did not have a 3CO (No 3CO) (remaining cohort). Rigid deformity was defined as ΔLL less than 33% from standing to supine. Severe deformity was defined as global (SVA > 70 mm) or C7-PL > 70 mm, or lumbopelvic (PI-LL > 30°). Means comparison tests assessed correction by 3CO grade/location. Multivariate analysis controlling for baseline deformity evaluated outcomes up to six weeks compared to No 3CO.<h4>Results</h4>648 patients were included (Mean age 61 ± 14.6 years, BMI 27.55 ± 5.8 kg/m², levels fused: 12.6 ± 3.8). 126 underwent 3CO, a 20% higher usage than historical cohorts. 3COs were older, frail, and more likely to undergo revision (OR 5.2, 95% CI [2.6-10.6]; p < .001). 3COs were more likely to present with both severe global/lumbopelvic deformity (OR 4), 62.4% being rigid. 3COs had greater use of secondary rods (OR 4st) and incurred 4 times greater risk for: massive blood loss (> 3500 mL), longer LOS, SICU admission, perioperative wound and spine-related complications, and neurologic complications when performed below L3. 3COs had similar HRQL benefit, but higher perioperative opioid use. Mean segmental correction increased by grade (G3-21; G4-24; G5-27) and was 4 × greater than low-grade osteotomies, especially below L3 (OR 12). 3COs achieved 2 × greater spinopelvic correction. Higher grades properly distributed lordosis 50% of the time except L5. Pelvic compensation and non-response were relieved more often with increasing grade, with greater correction in all lower extremity parameters (p < .01). Due to the increased rate of complications, 3COs trended toward higher perioperative cost ($42,806 vs. $40,046, p = .086).<h4>Conclusion</h4>Three-column osteotomy usage in contemporary complex spinal deformities is generally limited to more disabled individuals undergoing the most severe sagittal and coronal realignment procedures. While there is an increased perioperative cost and prolongation of length of stay with usage, these techniques represent the most powerful realignment techniques available with a dramatic impact on normalization at operative levels and reciprocal changes.International Spine Study GroupJournal article