Garnsey, Michelle RLim, DanielYost, Julianne MColtart, Don M2011-06-212011-06-212010Garnsey,Michelle R.;Lim,Daniel;Yost,Julianne M.;Coltart,Don M.. 2010. Development of a Strategy for the Asymmetric Synthesis of Polycyclic Polyprenylated Acylphloroglucinols via N-Amino Cyclic Carbamate Hydrazones: Application to the Total Synthesis of (+)-Clusianone. Organic letters 12(22): 5234-5237.1523-7060https://hdl.handle.net/10161/4109A broadly applicable asymmetric synthetic strategy utilizing N-amino cyclic carbamate alkylation that provides access to the various stereochemical permutations of a common structural motif found in many polycyclic polyprenylated acylphloroglucinols is described. The utility of this methodology is demonstrated through the first asymmetric total synthesis of the antiviral agent (+)-clusianone.en-USgarsubellin-abridgehead lithiationclusianone(+/-)-clusianoneketonesbenzophenonesderivativesnemorosonechemistry, organicDevelopment of a Strategy for the Asymmetric Synthesis of Polycyclic Polyprenylated Acylphloroglucinols via N-Amino Cyclic Carbamate Hydrazones: Application to the Total Synthesis of (+)-ClusianoneOther article