Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.

Naggie, SusannaSwiderska-Syn, MarzenaChoi, SteveLusk, SamLan, AudreyFerrari, GuidoSyn, Wing-KinGuy, Cynthia DDiehl, Anna Mae2023-03-022023-03-022018-072328-89572328-8957https://hdl.handle.net/10161/26708Liver disease is a leading cause of HIV-related mortality. Hepatitis C virus (HCV)-related fibrogenesis is accelerated in the setting of HIV coinfection, yet the mechanisms underlying this aggressive pathogenesis are unclear. We identified formalin-fixed paraffin-embedded liver tissue for HIV-infected patients, HCV-infected patients, HIV/HCV-coinfected patients, and controls at Duke University Medical Center. De-identified sections were stained for markers against the wound repair Hedgehog (Hh) pathway, resident T-lymphocytes, and immune activation and cellular aging. HIV infection was independently associated with Hh activation and markers of immune dysregulation in the liver tissue.GLIHedgehogSonic Hedgehogfibrogenesishepatitis C virushuman immunodeficiency viruspatchedpathogenesiswound repairMarkers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.Journal article2023-03-02