Matsouaka, Roland ASinghal, Aneesh BBetensky, Rebecca A2017-01-042016-01-01https://hdl.handle.net/10161/13352We consider a two-group randomized clinical trial, where mortality affects the assessment of a follow-up continuous outcome. Using the worst-rank composite endpoint, we develop a weighted Wilcoxon-Mann-Whitney test statistic to analyze the data. We determine the optimal weights for the Wilcoxon-Mann-Whitney test statistic that maximize its power. We derive a formula for its power and demonstrate its accuracy in simulations. Finally, we apply the method to data from an acute ischemic stroke clinical trial of normobaric oxygen therapy.Missing datacensored-by-deathcomposite endpointsmultiple endpointssurvivor biasweighted Wilcoxon–Mann–Whitney testJournal article1477-0334