Stafford-Smith, MarkLi, Yi-JuMathew, Joseph PLi, Yen-WeiJi, YunqiPhillips-Bute, Barbara GMilano, Carmelo ANewman, Mark FKraus, William EKertai, Miklos DShah, Svati HPodgoreanu, Mihai VDuke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team2017-03-012017-03-012015-10https://hdl.handle.net/10161/13721Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following coronary bypass graft (CABG) surgery. The discovery data set consisted of 873 nonemergent CABG surgery patients with cardiopulmonary bypass (PEGASUS), while a replication data set had 380 cardiac surgical patients (CATHGEN). Single-nucleotide polymorphism (SNP) data were based on Illumina Human610-Quad (PEGASUS) and OMNI1-Quad (CATHGEN) BeadChips. We used linear regression with adjustment for a clinical AKI risk score to test SNP associations with the postoperative peak rise relative to preoperative serum creatinine concentration as a quantitative AKI trait. Nine SNPs meeting significance in the discovery set were detected. The rs13317787 in GRM7|LMCD1-AS1 intergenic region (3p21.6) and rs10262995 in BBS9 (7p14.3) were replicated with significance in the CATHGEN data set and exhibited significantly strong overall association following meta-analysis. Additional fine mapping using imputed SNPs across these two regions and meta-analysis found genome-wide significance at the GRM7|LMCD1-AS1 locus and a significantly strong association at BBS9. Thus, through an unbiased GWAS approach, we found two new loci associated with post-CABG AKI providing new insights into the pathogenesis of perioperative AKI.Acute Kidney InjuryAgedBiomarkersCoronary Artery BypassCreatinineDatabases, GeneticFemaleGenetic LociGenetic MarkersGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLinear ModelsMaleMiddle AgedPhenotypePolymorphism, Single NucleotideRisk AssessmentRisk FactorsTime FactorsJournal article1523-1755