Wang, MengyunLi, QiaoxinGu, ChengyuanZhu, YaoYang, YajunWang, JiucunJin, LiHe, JingYe, DingweiWei, Qingyi2019-02-012019-02-012017-041949-25531949-2553https://hdl.handle.net/10161/17945Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated for their roles in the development of prostate cancer (PCa); however, the published results have been inconsistent. In a hospital-based case-control study of 1,004 PCa cases and 1,055 cancer-free controls, we genotyped eight potentially functional single nucleotide polymorphisms (SNPs) of NER genes (i.e., XPC, rs2228001 T>G and rs1870134 G>C; XPD, rs13181 T>G and rs238406 G>T; XPG, rs1047768 T>C, rs751402 C>T, and rs17655 G>C; and XPF, rs2276464 G>C) and assessed their associations with risk of PCa by using logistic regression analysis. Among these eight SNPs investigated, only XPC rs1870134 CG/CC variant genotypes were associated with a decreased risk of prostate cancer under a dominant genetic model (adjusted odds ratio [OR] = 0.77, 95% confidence interval [CI] = 0.64-1.91, P = 0.003). Phenotype-genotype analysis also suggested that the XPC rs1870134 CG/CC variant genotypes were associated with significantly decreased expression levels of XPC mRNA in a mix population of different ethnicities. These findings suggested that XPC SNPs may contribute to risk of PCa in Eastern Chinese men.HumansProstatic NeoplasmsGenetic Predisposition to DiseaseRNA, MessengerRisk FactorsCase-Control StudiesDNA RepairPolymorphism, Single NucleotideAgedMiddle AgedAsian Continental Ancestry GroupFemaleMaleJournal article2019-02-01