Roxin, AlexBrunel, NicolasHansel, DavidMongillo, Gianluigivan Vreeswijk, Carl2021-06-062021-06-062011-110270-64741529-2401https://hdl.handle.net/10161/23361The distribution of in vivo average firing rates within local cortical networks has been reported to be highly skewed and long tailed. The distribution of average single-cell inputs, conversely, is expected to be Gaussian by the central limit theorem. This raises the issue of how a skewed distribution of firing rates might result from a symmetric distribution of inputs. We argue that skewed rate distributions are a signature of the nonlinearity of the in vivo f-I curve. During in vivo conditions, ongoing synaptic activity produces significant fluctuations in the membrane potential of neurons, resulting in an expansive nonlinearity of the f-I curve for low and moderate inputs. Here, we investigate the effects of single-cell and network parameters on the shape of the f-I curve and, by extension, on the distribution of firing rates in randomly connected networks.Cerebral CortexNerve NetNeuronsAnimalsNormal DistributionAction PotentialsNeural InhibitionNonlinear DynamicsModels, NeurologicalTime FactorsComputer SimulationJournal article2021-06-06