Smith, Justin SShaffrey, Christopher IKim, Han JoPassias, PeterProtopsaltis, ThemistoclesLafage, RenaudMundis, Gregory MKlineberg, EricLafage, VirginieSchwab, Frank JScheer, Justin KMiller, EmilyKelly, MichaelHamilton, D KojoGupta, MunishDeviren, VedatHostin, RichardAlbert, ToddRiew, K DanielHart, RobertBurton, DougBess, ShayAmes, Christopher PInternational Spine Study Group2023-06-202023-06-202018-120148-396X1524-4040https://hdl.handle.net/10161/28231BACKGROUND:Surgical treatments for adult cervical spinal deformity (ACSD) are often complex and have high complication rates. OBJECTIVE:To assess all-cause mortality following ACSD surgery. METHODS:ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database. Clinical and surgical parameters and all-cause mortality were assessed. RESULTS:Of 123 ACSD patients, 120 (98%) had complete baseline data (mean age, 60.6 yr). The mean number of comorbidities per patient was 1.80, and 80% had at least 1 comorbidity. Surgical approaches included anterior only (15.8%), posterior only (50.0%), and combined anterior/posterior (34.2%). The mean number of vertebral levels fused was 8.0 (standard deviation [SD] = 4.5), and 23.3% had a 3-column osteotomy. Death was reported for 11 (9.2%) patients at a mean of 1.1 yr (SD = 0.76 yr; range = 7 d to 2 yr). Mean follow-up for living patients was 1.2 yr (SD = 0.64 yr). Causes of death included myocardial infarction (n = 2), pneumonia/cardiopulmonary failure (n = 2), sepsis (n = 1), obstructive sleep apnea/narcotics (n = 1), subsequently diagnosed amyotrophic lateral sclerosis (n = 1), burn injury related to home supplemental oxygen (n = 1), and unknown (n = 3). Deceased patients did not significantly differ from alive patients based on demographic, clinical, or surgical parameters assessed, except for a higher major complication rate (excluding mortality; 63.6% vs 22.0%, P = .006). CONCLUSION:All-cause mortality at a mean of 1.2 yr following surgery for ACSD was 9.2% in this prospective multicenter series. Causes of death were reflective of the overall high level of comorbidities. These findings may prove useful for treatment decision making and patient counseling in the context of the substantial impact of ACSD.International Spine Study GroupCervical VertebraeHumansSpinal CurvaturesOsteotomyProspective StudiesComorbidityAdultAgedMiddle AgedFemaleMaleJournal article2023-06-20